| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 35 | 35 | 22 | 5 | 2.71 | .269 | 1.05 | 7.0 | 2.5 | 10.7 | 212.1 | 165 | 66 | 64 | 17 | 59 | 251 | 0 | 0 | 0 | 0 | 24 | 11 | 0 | 2.67 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 90 | 33 | 33 | 17 | 7 | 3.69 | .285 | 1.14 | 8.3 | 2.0 | 5.8 | 217.0 | 199 | 90 | 89 | 21 | 49 | 141 | 5 | 0 | 0 | 1 | 21 | 12 | 5 | 3.80 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 82 | 31 | 31 | 22 | 4 | 2.49 | .279 | 1.15 | 6.4 | 3.9 | 8.6 | 195.1 | 139 | 55 | 54 | 13 | 85 | 186 | 1 | 0 | 0 | 0 | 21 | 3 | 0 | 3.31 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 30 | 29 | 13 | 5 | 3.11 | .276 | 1.10 | 6.7 | 3.3 | 8.8 | 176.2 | 131 | 63 | 61 | 12 | 64 | 173 | 0 | 0 | 0 | 0 | 16 | 7 | 7 | 3.13 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 38 | 0 | 5 | 0 | 2.72 | .277 | 1.11 | 5.3 | 4.8 | 8.6 | 49.2 | 29 | 15 | 15 | 0 | 26 | 47 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 2.80 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 36 | 0 | 2 | 0 | 3.55 | .331 | 1.42 | 6.3 | 6.5 | 7.9 | 33.0 | 23 | 13 | 13 | 2 | 24 | 29 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.39 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 68 | 44 | 0 | 0 | 1 | 4.01 | .292 | 1.24 | 6.9 | 4.4 | 10.2 | 51.2 | 39 | 23 | 23 | 8 | 25 | 58 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.24 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 92 | 78 | 0 | 5 | 2 | 1.63 | .248 | 0.96 | 5.0 | 3.6 | 11.7 | 82.2 | 46 | 15 | 15 | 5 | 33 | 107 | 0 | 6 | 3 | 0 | 0 | 3 | 1 | 2.50 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 73 | 0 | 6 | 5 | 1.93 | .209 | 0.74 | 5.5 | 1.3 | 10.9 | 79.1 | 48 | 17 | 17 | 9 | 11 | 96 | 0 | 50 | 3 | 0 | 0 | 4 | 0 | 2.62 |