| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 37 | 37 | 16 | 14 | 4.00 | .301 | 1.26 | 8.0 | 3.4 | 9.1 | 265.2 | 236 | 120 | 118 | 28 | 99 | 268 | 4 | 0 | 0 | 2 | 23 | 9 | 5 | 3.57 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 35 | 35 | 11 | 11 | 5.38 | .330 | 1.47 | 9.0 | 4.2 | 9.8 | 207.1 | 208 | 125 | 124 | 34 | 96 | 225 | 0 | 0 | 0 | 0 | 13 | 2 | 5 | 4.38 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 75 | 34 | 34 | 14 | 14 | 4.40 | .317 | 1.36 | 9.0 | 3.3 | 6.8 | 258.0 | 257 | 133 | 126 | 32 | 94 | 195 | 12 | 0 | 0 | 2 | 17 | 9 | 8 | 4.30 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 33 | 33 | 14 | 14 | 4.95 | .330 | 1.45 | 9.8 | 3.3 | 6.7 | 243.2 | 265 | 135 | 134 | 24 | 88 | 180 | 12 | 0 | 0 | 3 | 12 | 7 | 10 | 3.98 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 34 | 31 | 15 | 14 | 5.62 | .331 | 1.46 | 10.2 | 3.0 | 9.0 | 224.1 | 254 | 145 | 140 | 42 | 74 | 224 | 4 | 1 | 0 | 0 | 12 | 5 | 7 | 4.50 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 98 | 0 | 6 | 4 | 2.77 | .292 | 1.20 | 6.3 | 4.5 | 8.7 | 123.2 | 86 | 42 | 38 | 9 | 62 | 119 | 0 | 15 | 2 | 0 | 0 | 5 | 4 | 3.65 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 71 | 67 | 0 | 5 | 4 | 2.92 | .313 | 1.34 | 7.6 | 4.4 | 9.3 | 71.0 | 60 | 28 | 23 | 7 | 35 | 73 | 0 | 9 | 2 | 0 | 0 | 2 | 3 | 3.79 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 50 | 37 | 0 | 1 | 2 | 8.74 | .375 | 1.80 | 9.5 | 6.7 | 10.0 | 35.0 | 37 | 34 | 34 | 11 | 26 | 39 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 7.09 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 33 | 41 | 0 | 1 | 2 | 3.74 | .340 | 1.52 | 7.5 | 6.3 | 10.3 | 43.1 | 36 | 20 | 18 | 5 | 30 | 49 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.40 |