| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 20 | 20 | 7 | 10 | 4.51 | .316 | 1.34 | 7.4 | 4.8 | 9.8 | 125.2 | 103 | 68 | 63 | 15 | 66 | 136 | 0 | 0 | 0 | 0 | 12 | 5 | 4 | 4.09 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 18 | 18 | 6 | 9 | 4.77 | .340 | 1.52 | 9.8 | 4.0 | 9.2 | 105.2 | 114 | 60 | 56 | 18 | 47 | 107 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4.59 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 18 | 18 | 1 | 10 | 6.28 | .337 | 1.47 | 10.2 | 3.2 | 10.6 | 77.1 | 87 | 59 | 54 | 15 | 27 | 91 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 4.38 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 65 | 18 | 18 | 8 | 3 | 4.26 | .326 | 1.41 | 9.8 | 3.0 | 5.7 | 131.0 | 142 | 65 | 62 | 14 | 43 | 83 | 1 | 0 | 0 | 0 | 10 | 5 | 3 | 4.22 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 49 | 0 | 6 | 2 | 1.94 | .239 | 0.92 | 5.1 | 3.3 | 8.8 | 83.2 | 47 | 19 | 18 | 9 | 30 | 81 | 0 | 9 | 4 | 0 | 0 | 2 | 0 | 3.61 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 36 | 0 | 5 | 2 | 4.50 | .287 | 1.13 | 7.3 | 2.8 | 9.0 | 48.0 | 39 | 24 | 24 | 4 | 15 | 48 | 0 | 3 | 0 | 0 | 0 | 4 | 0 | 3.27 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 32 | 0 | 1 | 0 | 5.00 | .353 | 1.61 | 7.8 | 6.8 | 10.3 | 36.0 | 31 | 23 | 20 | 3 | 27 | 41 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 4.14 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 23 | 0 | 3 | 2 | 4.26 | .321 | 1.42 | 11.8 | 0.9 | 10.9 | 19.0 | 25 | 9 | 9 | 2 | 2 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.26 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 17 | 0 | 1 | 0 | 3.86 | .291 | 1.23 | 8.5 | 3.0 | 7.0 | 18.2 | 17 | 8 | 8 | 2 | 6 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 64 | 11 | 0 | 1 | 0 | 5.79 | .250 | 1.00 | 7.1 | 1.9 | 11.6 | 14.0 | 11 | 9 | 9 | 3 | 3 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.86 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 16 | 0 | 0 | 0 | 3.47 | .300 | 1.24 | 8.6 | 2.7 | 9.8 | 23.1 | 22 | 11 | 9 | 1 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.43 |