| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 33 | 33 | 11 | 18 | 3.33 | .296 | 1.24 | 7.8 | 3.4 | 5.4 | 256.2 | 221 | 108 | 95 | 17 | 96 | 153 | 8 | 0 | 0 | 2 | 20 | 7 | 4 | 3.88 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 32 | 32 | 15 | 10 | 4.98 | .321 | 1.40 | 8.5 | 4.1 | 8.6 | 209.2 | 198 | 119 | 116 | 27 | 95 | 199 | 0 | 0 | 0 | 0 | 15 | 4 | 5 | 4.20 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 32 | 32 | 16 | 8 | 4.31 | .308 | 1.31 | 9.4 | 2.4 | 7.6 | 240.0 | 251 | 119 | 115 | 31 | 64 | 202 | 9 | 0 | 0 | 1 | 18 | 5 | 3 | 3.86 |
| SP | Cicotte, E.Cicotte, Eddie † >> | 33 | 1917 | R | 74 | 32 | 32 | 18 | 12 | 4.13 | .318 | 1.39 | 9.0 | 3.5 | 4.5 | 233.0 | 232 | 120 | 107 | 17 | 91 | 117 | 9 | 0 | 0 | 2 | 16 | 3 | 4 | 4.15 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 30 | 30 | 14 | 13 | 4.87 | .322 | 1.41 | 9.4 | 3.3 | 5.3 | 229.0 | 240 | 132 | 124 | 24 | 84 | 135 | 8 | 0 | 0 | 1 | 12 | 3 | 8 | 4.32 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 78 | 0 | 5 | 1 | 2.33 | .265 | 1.07 | 6.2 | 3.4 | 8.9 | 85.0 | 59 | 26 | 22 | 9 | 32 | 84 | 0 | 15 | 3 | 0 | 0 | 1 | 0 | 3.56 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 18 | 0 | 1 | 1 | 1.44 | .176 | 0.64 | 3.6 | 2.2 | 9.0 | 25.0 | 10 | 4 | 4 | 0 | 6 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.72 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 22 | 0 | 0 | 0 | 1.32 | .241 | 0.95 | 5.0 | 3.7 | 8.0 | 27.1 | 15 | 4 | 4 | 0 | 11 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.44 |