| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 34 | 34 | 14 | 10 | 3.58 | .295 | 1.24 | 8.5 | 2.7 | 9.4 | 218.2 | 205 | 100 | 87 | 19 | 66 | 228 | 2 | 0 | 0 | 1 | 20 | 4 | 4 | 3.00 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 34 | 34 | 8 | 16 | 4.67 | .315 | 1.36 | 9.4 | 2.8 | 8.7 | 212.0 | 222 | 111 | 110 | 30 | 67 | 206 | 6 | 0 | 0 | 1 | 18 | 4 | 6 | 3.90 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 33 | 33 | 10 | 14 | 6.16 | .354 | 1.61 | 10.6 | 3.9 | 5.8 | 188.1 | 221 | 135 | 129 | 16 | 82 | 121 | 1 | 0 | 0 | 1 | 11 | 6 | 5 | 4.22 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 92 | 0 | 7 | 5 | 4.33 | .325 | 1.43 | 8.3 | 4.7 | 8.8 | 114.1 | 105 | 59 | 55 | 14 | 59 | 112 | 0 | 13 | 3 | 0 | 0 | 1 | 1 | 4.21 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 81 | 0 | 8 | 7 | 4.15 | .333 | 1.47 | 8.4 | 4.9 | 9.6 | 97.2 | 91 | 47 | 45 | 14 | 53 | 104 | 0 | 8 | 4 | 0 | 0 | 2 | 7 | 4.43 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 64 | 0 | 5 | 4 | 4.21 | .313 | 1.31 | 8.5 | 3.3 | 9.8 | 77.0 | 73 | 37 | 36 | 8 | 28 | 84 | 0 | 7 | 3 | 0 | 0 | 4 | 5 | 3.42 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 54 | 0 | 3 | 6 | 2.78 | .249 | 1.00 | 6.1 | 2.9 | 9.0 | 71.1 | 48 | 26 | 22 | 9 | 23 | 71 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 3.62 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 31 | 0 | 1 | 1 | 4.50 | .382 | 1.79 | 11.9 | 4.2 | 7.1 | 34.0 | 45 | 17 | 17 | 2 | 16 | 27 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 3.76 |