| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 18 | 18 | 4 | 10 | 4.08 | .304 | 1.29 | 8.5 | 3.2 | 9.7 | 132.1 | 124 | 62 | 60 | 15 | 47 | 142 | 3 | 0 | 0 | 0 | 11 | 2 | 2 | 3.44 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 2 | 8 | 5.55 | .320 | 1.40 | 9.1 | 3.6 | 8.6 | 118.1 | 119 | 75 | 73 | 17 | 47 | 113 | 0 | 0 | 0 | 0 | 6 | 1 | 3 | 4.18 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 17 | 17 | 8 | 6 | 5.88 | .324 | 1.43 | 9.6 | 3.3 | 5.4 | 124.0 | 132 | 85 | 81 | 19 | 45 | 75 | 7 | 0 | 0 | 0 | 4 | 1 | 4 | 4.90 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 17 | 17 | 9 | 6 | 5.08 | .315 | 1.38 | 9.2 | 3.2 | 4.4 | 125.2 | 128 | 76 | 71 | 18 | 45 | 61 | 4 | 0 | 0 | 1 | 6 | 0 | 0 | 4.98 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 32 | 0 | 5 | 3 | 5.50 | .323 | 1.41 | 9.2 | 3.6 | 8.8 | 37.2 | 38 | 24 | 23 | 5 | 15 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.11 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 25 | 0 | 1 | 0 | 4.44 | .282 | 1.18 | 8.0 | 2.8 | 7.3 | 26.1 | 23 | 14 | 13 | 1 | 8 | 21 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 2.81 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 18 | 0 | 4 | 1 | 3.80 | .238 | 0.94 | 5.6 | 3.0 | 8.1 | 21.1 | 13 | 9 | 9 | 0 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.19 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 14 | 0 | 1 | 1 | 4.50 | .270 | 1.11 | 5.0 | 5.0 | 5.5 | 18.0 | 10 | 9 | 9 | 4 | 10 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.33 |