| SP | Springs, J.Springs, Jeffrey # >> | 29 | 2022 | L | 51 | 34 | 33 | 3 | 15 | 7.91 | .371 | 1.77 | 12.1 | 3.9 | 8.1 | 118.1 | 158 | 108 | 104 | 29 | 51 | 106 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 5.69 |
| SP | Odorizzi, J.Odorizzi, Jake >> | 25 | 2015 | R | 41 | 33 | 33 | 5 | 24 | 6.75 | .353 | 1.62 | 10.9 | 3.7 | 6.6 | 152.0 | 184 | 119 | 114 | 30 | 62 | 112 | 0 | 0 | 0 | 0 | 11 | 3 | 7 | 5.38 |
| SP | Garza, M.Garza, Matt # >> | 26 | 2009 | R | 39 | 34 | 32 | 10 | 13 | 4.16 | .292 | 1.21 | 7.8 | 3.1 | 6.6 | 201.1 | 174 | 93 | 93 | 34 | 70 | 147 | 0 | 1 | 0 | 0 | 17 | 5 | 1 | 4.86 |
| SP | Kazmir, S.Kazmir, Scott >> | 21 | 2005 | L | 29 | 32 | 31 | 6 | 16 | 4.64 | .343 | 1.55 | 8.4 | 5.5 | 7.2 | 159.0 | 149 | 87 | 82 | 16 | 97 | 128 | 0 | 0 | 1 | 0 | 10 | 3 | 2 | 4.58 |
| RP | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 80 | 115 | 0 | 7 | 4 | 3.64 | .289 | 1.21 | 6.2 | 4.8 | 9.4 | 150.2 | 103 | 62 | 61 | 13 | 80 | 156 | 0 | 12 | 3 | 0 | 0 | 1 | 4 | 3.67 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 102 | 0 | 5 | 5 | 4.34 | .303 | 1.29 | 8.6 | 3.0 | 9.2 | 124.1 | 118 | 60 | 60 | 20 | 42 | 127 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 4.11 |
| RP | Hernandez, R.Hernandez, Roberto >> | 35 | 1999 | R | 15 | 71 | 0 | 0 | 5 | 5.36 | .332 | 1.46 | 8.6 | 4.6 | 6.2 | 84.0 | 80 | 50 | 50 | 12 | 43 | 58 | 0 | 6 | 2 | 0 | 0 | 2 | 1 | 5.08 |