| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 31 | 31 | 15 | 9 | 3.24 | .274 | 1.11 | 6.7 | 3.2 | 5.4 | 203.0 | 152 | 76 | 73 | 16 | 73 | 121 | 2 | 0 | 0 | 1 | 22 | 5 | 3 | 3.99 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 30 | 30 | 21 | 4 | 2.84 | .283 | 1.17 | 5.9 | 4.6 | 4.3 | 212.2 | 140 | 71 | 67 | 9 | 109 | 101 | 3 | 0 | 0 | 0 | 22 | 3 | 5 | 4.18 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 30 | 29 | 13 | 8 | 3.96 | .320 | 1.39 | 7.6 | 4.9 | 3.8 | 168.0 | 142 | 79 | 74 | 12 | 92 | 71 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 4.78 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 97 | 0 | 6 | 0 | 1.70 | .263 | 1.07 | 4.8 | 4.8 | 8.7 | 69.0 | 37 | 14 | 13 | 1 | 37 | 67 | 0 | 5 | 1 | 0 | 0 | 0 | 3 | 2.86 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 92 | 0 | 2 | 2 | 2.47 | .253 | 1.00 | 5.8 | 3.2 | 8.1 | 62.0 | 40 | 20 | 17 | 3 | 22 | 56 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 2.94 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 81 | 0 | 3 | 2 | 1.56 | .196 | 0.73 | 4.0 | 2.6 | 8.8 | 52.0 | 23 | 12 | 9 | 3 | 15 | 51 | 0 | 11 | 2 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 77 | 0 | 3 | 0 | 1.54 | .233 | 0.89 | 4.0 | 4.2 | 9.5 | 52.2 | 23 | 9 | 9 | 3 | 24 | 55 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 3.08 |
| RP | Messersmith, A.Messersmith, Andy † >> | 23 | 1968 | R | 58 | 61 | 0 | 6 | 0 | 1.79 | .234 | 0.91 | 4.5 | 3.8 | 5.9 | 50.1 | 25 | 12 | 10 | 4 | 21 | 33 | 0 | 18 | 2 | 0 | 0 | 0 | 4 | 3.98 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 31 | 0 | 3 | 0 | 1.35 | .248 | 0.99 | 6.0 | 3.0 | 8.7 | 33.1 | 22 | 5 | 5 | 1 | 11 | 32 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 2.45 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 72 | 0 | 3 | 2 | 1.41 | .257 | 1.04 | 5.9 | 3.6 | 7.1 | 63.2 | 41 | 11 | 10 | 3 | 25 | 50 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.22 |