| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 31 | 31 | 10 | 15 | 3.74 | .296 | 1.24 | 8.8 | 2.3 | 4.7 | 170.2 | 167 | 75 | 71 | 19 | 44 | 88 | 0 | 0 | 0 | 0 | 11 | 4 | 5 | 4.26 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 30 | 30 | 7 | 16 | 4.80 | .328 | 1.44 | 9.4 | 3.6 | 8.2 | 187.2 | 196 | 111 | 100 | 31 | 74 | 170 | 3 | 0 | 0 | 1 | 16 | 5 | 1 | 4.60 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 30 | 29 | 6 | 14 | 4.90 | .325 | 1.40 | 8.8 | 3.8 | 4.7 | 150.2 | 147 | 88 | 82 | 21 | 64 | 78 | 0 | 0 | 0 | 0 | 9 | 7 | 5 | 5.20 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 29 | 29 | 6 | 13 | 4.92 | .311 | 1.33 | 8.8 | 3.2 | 8.3 | 188.1 | 184 | 106 | 103 | 22 | 67 | 174 | 1 | 0 | 0 | 1 | 10 | 4 | 2 | 3.80 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 31 | 28 | 9 | 13 | 7.23 | .345 | 1.54 | 10.6 | 3.3 | 6.5 | 145.2 | 171 | 120 | 117 | 27 | 53 | 104 | 0 | 1 | 0 | 0 | 7 | 6 | 13 | 5.21 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 73 | 0 | 2 | 7 | 4.07 | .318 | 1.33 | 9.0 | 3.0 | 8.3 | 73.0 | 73 | 33 | 33 | 7 | 24 | 67 | 0 | 27 | 2 | 0 | 0 | 5 | 1 | 3.60 |
| SU | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 81 | 0 | 2 | 3 | 2.64 | .274 | 1.12 | 6.4 | 3.7 | 8.5 | 99.0 | 70 | 32 | 29 | 5 | 41 | 93 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.05 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 92 | 0 | 4 | 5 | 3.98 | .282 | 1.16 | 6.7 | 3.8 | 7.5 | 115.1 | 86 | 53 | 51 | 12 | 48 | 96 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 3.99 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 78 | 0 | 1 | 6 | 4.10 | .298 | 1.24 | 8.2 | 3.1 | 7.0 | 96.2 | 87 | 44 | 44 | 8 | 33 | 75 | 0 | 2 | 3 | 0 | 0 | 3 | 0 | 3.65 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 71 | 0 | 5 | 3 | 5.82 | .350 | 1.59 | 10.0 | 4.4 | 6.0 | 86.2 | 96 | 56 | 56 | 15 | 42 | 57 | 0 | 3 | 1 | 0 | 0 | 2 | 5 | 5.48 |