| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 25 | 25 | 12 | 7 | 3.31 | .274 | 1.12 | 7.6 | 2.5 | 8.0 | 182.0 | 153 | 71 | 67 | 16 | 51 | 161 | 5 | 0 | 0 | 2 | 17 | 2 | 4 | 3.25 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 92 | 25 | 25 | 13 | 6 | 3.61 | .279 | 1.16 | 7.8 | 2.7 | 5.0 | 189.1 | 163 | 77 | 76 | 16 | 56 | 105 | 13 | 0 | 0 | 3 | 13 | 1 | 5 | 3.89 |
| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 84 | 24 | 24 | 14 | 4 | 3.83 | .303 | 1.29 | 9.2 | 2.5 | 8.3 | 171.2 | 174 | 76 | 73 | 20 | 48 | 157 | 7 | 0 | 0 | 1 | 14 | 2 | 6 | 3.56 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 24 | 24 | 10 | 8 | 3.17 | .297 | 1.23 | 6.9 | 4.2 | 8.3 | 164.2 | 126 | 67 | 58 | 14 | 77 | 152 | 1 | 0 | 0 | 0 | 17 | 6 | 4 | 3.77 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 58 | 0 | 6 | 3 | 2.23 | .221 | 0.83 | 5.6 | 1.9 | 8.0 | 72.2 | 45 | 20 | 18 | 5 | 15 | 64 | 0 | 16 | 2 | 0 | 0 | 2 | 1 | 2.83 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 33 | 0 | 2 | 1 | 3.03 | .261 | 1.06 | 6.4 | 3.3 | 8.3 | 38.2 | 27 | 14 | 13 | 3 | 14 | 35 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.29 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 18 | 0 | 3 | 2 | 3.38 | .256 | 1.03 | 7.3 | 2.1 | 6.0 | 21.1 | 17 | 9 | 8 | 4 | 5 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.86 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 14 | 0 | 1 | 1 | 2.84 | .224 | 0.79 | 4.5 | 3.0 | 9.8 | 12.2 | 6 | 4 | 4 | 3 | 4 | 13 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.33 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 13 | 0 | 1 | 1 | 7.04 | .324 | 1.24 | 6.6 | 4.8 | 8.4 | 15.1 | 11 | 12 | 12 | 3 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.93 |