| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 31 | 31 | 15 | 12 | 3.80 | .296 | 1.24 | 7.9 | 3.2 | 8.7 | 244.0 | 214 | 103 | 103 | 32 | 88 | 236 | 8 | 0 | 0 | 3 | 18 | 6 | 1 | 3.93 |
| SP | Arrieta, J.Arrieta, Jake $$ >> | 29 | 2015 | R | 92 | 29 | 29 | 11 | 7 | 4.83 | .303 | 1.28 | 8.6 | 3.0 | 7.7 | 201.1 | 192 | 110 | 108 | 25 | 66 | 172 | 4 | 0 | 0 | 2 | 14 | 4 | 7 | 3.95 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 29 | 29 | 8 | 11 | 4.44 | .325 | 1.42 | 9.0 | 3.8 | 7.1 | 190.1 | 191 | 101 | 94 | 20 | 80 | 150 | 0 | 0 | 0 | 0 | 12 | 4 | 2 | 4.12 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 28 | 28 | 9 | 6 | 4.35 | .337 | 1.49 | 9.5 | 4.0 | 7.7 | 138.2 | 145 | 73 | 67 | 17 | 62 | 118 | 0 | 0 | 0 | 0 | 3 | 4 | 4 | 4.33 |
| RP | Gagne, E.Gagne, Eric † $ >> | 27 | 2003 | R | 98 | 72 | 0 | 8 | 2 | 3.03 | .260 | 1.05 | 6.4 | 3.1 | 8.5 | 92.0 | 65 | 32 | 31 | 11 | 32 | 87 | 0 | 11 | 1 | 0 | 0 | 0 | 1 | 3.71 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 50 | 0 | 5 | 1 | 1.73 | .226 | 0.85 | 4.1 | 3.6 | 8.5 | 73.0 | 33 | 14 | 14 | 3 | 29 | 69 | 0 | 10 | 2 | 0 | 0 | 2 | 0 | 2.92 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 32 | 0 | 4 | 3 | 1.14 | .263 | 1.04 | 6.9 | 2.5 | 8.5 | 39.1 | 30 | 5 | 5 | 1 | 11 | 37 | 0 | 4 | 3 | 0 | 0 | 1 | 4 | 2.36 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 21 | 0 | 2 | 4 | 3.48 | .295 | 1.26 | 6.8 | 5.0 | 10.8 | 20.2 | 15 | 8 | 8 | 2 | 11 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.55 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 23 | 0 | 3 | 0 | 3.81 | .310 | 1.35 | 9.3 | 2.8 | 10.7 | 26.0 | 27 | 11 | 11 | 3 | 8 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.04 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 17 | 0 | 7 | 3 | 4.32 | .324 | 1.43 | 9.1 | 3.7 | 6.8 | 75.0 | 76 | 42 | 36 | 7 | 31 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 3.97 |