| SP | Buchholz, C.Buchholz, Clay >> | 34 | 2018 | R | 51 | 15 | 15 | 5 | 6 | 3.46 | .301 | 1.27 | 7.8 | 3.7 | 5.5 | 101.1 | 88 | 39 | 39 | 6 | 41 | 62 | 2 | 0 | 0 | 0 | 8 | 2 | 0 | 3.82 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 50 | 15 | 15 | 1 | 11 | 7.24 | .398 | 1.93 | 13.4 | 4.2 | 5.6 | 64.2 | 95 | 56 | 52 | 14 | 30 | 40 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 6.14 |
| SP | Kelly, M.Kelly, Merrill # >> | 33 | 2022 | R | 46 | 15 | 15 | 3 | 8 | 4.53 | .307 | 1.33 | 8.9 | 3.1 | 6.6 | 93.1 | 92 | 47 | 47 | 10 | 32 | 68 | 0 | 0 | 0 | 0 | 8 | 0 | 3 | 3.97 |
| SP | Johnson, R.Johnson, Randy >> | 45 | 2008 | L | 39 | 15 | 15 | 3 | 10 | 7.05 | .372 | 1.76 | 11.2 | 4.8 | 5.1 | 81.2 | 101 | 64 | 64 | 10 | 43 | 46 | 0 | 0 | 0 | 0 | 5 | 1 | 5 | 5.10 |
| RP | Kim, B.Kim, Byung-Hyun >> | 22 | 2001 | R | 52 | 48 | 0 | 3 | 5 | 3.50 | .316 | 1.38 | 7.2 | 5.3 | 6.8 | 64.1 | 51 | 27 | 25 | 5 | 38 | 48 | 0 | 5 | 5 | 0 | 0 | 0 | 4 | 4.30 |
| RP | Ziegler, B.Ziegler, Brad >> | 36 | 2015 | R | 44 | 43 | 0 | 1 | 1 | 3.42 | .304 | 1.31 | 7.4 | 4.5 | 5.7 | 52.2 | 43 | 23 | 20 | 3 | 26 | 33 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.98 |
| RP | Bradley, A.Bradley, Archie >> | 24 | 2017 | R | 43 | 38 | 0 | 2 | 2 | 3.31 | .283 | 1.14 | 7.2 | 3.1 | 6.8 | 49.0 | 39 | 18 | 18 | 3 | 17 | 37 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.45 |
| RP | Valverde, J.Valverde, Jose >> | 28 | 2007 | R | 40 | 32 | 0 | 0 | 0 | 3.00 | .288 | 1.21 | 7.9 | 3.0 | 8.6 | 42.0 | 37 | 14 | 14 | 4 | 14 | 40 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 3.33 |
| RP | Villarreal, O.Villarreal, Oscar >> | 22 | 2003 | R | 24 | 25 | 0 | 0 | 0 | 3.30 | .333 | 1.47 | 8.1 | 5.1 | 3.3 | 30.0 | 27 | 11 | 11 | 2 | 17 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.93 |