| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 12 | 12 | 5 | 5 | 4.21 | .317 | 1.39 | 9.1 | 3.4 | 7.6 | 77.0 | 78 | 39 | 36 | 3 | 29 | 65 | 0 | 0 | 0 | 0 | 6 | 0 | 4 | 2.95 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 72 | 12 | 12 | 6 | 6 | 4.17 | .332 | 1.45 | 8.2 | 4.8 | 4.5 | 82.0 | 75 | 44 | 38 | 4 | 44 | 41 | 1 | 0 | 0 | 1 | 6 | 3 | 1 | 4.35 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 12 | 12 | 8 | 2 | 3.14 | .255 | 1.02 | 7.1 | 2.0 | 6.2 | 97.1 | 77 | 34 | 34 | 8 | 22 | 67 | 8 | 0 | 0 | 1 | 9 | 1 | 0 | 3.40 |
| SP | Brown, M.Brown, Mordecai >> | 28 | 1904 | R | 63 | 12 | 12 | 6 | 5 | 4.69 | .339 | 1.54 | 9.9 | 4.1 | 4.2 | 80.2 | 88 | 44 | 42 | 4 | 36 | 37 | 2 | 0 | 0 | 1 | 5 | 0 | 0 | 4.08 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 31 | 0 | 0 | 0 | 4.30 | .294 | 1.22 | 7.1 | 4.1 | 11.7 | 37.2 | 29 | 18 | 18 | 5 | 17 | 48 | 0 | 4 | 1 | 0 | 0 | 1 | 4 | 3.62 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 96 | 27 | 0 | 0 | 2 | 5.79 | .333 | 1.44 | 7.9 | 5.3 | 9.6 | 32.2 | 28 | 21 | 21 | 3 | 19 | 34 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 4.06 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 83 | 22 | 0 | 2 | 0 | 3.16 | .313 | 1.36 | 9.4 | 3.2 | 9.4 | 25.2 | 26 | 9 | 9 | 1 | 9 | 26 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.52 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 92 | 14 | 0 | 1 | 2 | 2.60 | .307 | 1.33 | 5.8 | 6.4 | 10.1 | 17.1 | 11 | 5 | 5 | 1 | 12 | 19 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 3.65 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 74 | 12 | 0 | 0 | 1 | 6.10 | .446 | 2.23 | 13.5 | 7.2 | 8.1 | 10.1 | 15 | 7 | 7 | 1 | 8 | 9 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 5.50 |
| RP | Miller, T.Miller, Tyson >> | 28 | 2024 | R | 73 | 9 | 0 | 0 | 0 | 4.09 | .283 | 1.18 | 7.4 | 3.3 | 8.2 | 11.0 | 9 | 5 | 5 | 1 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.45 |