| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 98 | 23 | 23 | 15 | 6 | 3.07 | .288 | 1.20 | 8.1 | 2.8 | 7.5 | 152.1 | 136 | 56 | 52 | 12 | 47 | 127 | 2 | 0 | 0 | 2 | 15 | 2 | 9 | 3.32 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 89 | 23 | 23 | 0 | 5 | 5.69 | .364 | 1.65 | 8.6 | 6.2 | 10.3 | 49.0 | 47 | 37 | 31 | 5 | 34 | 56 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.31 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 71 | 21 | 21 | 12 | 2 | 2.99 | .278 | 1.14 | 6.2 | 4.1 | 5.3 | 135.2 | 93 | 45 | 45 | 10 | 62 | 79 | 4 | 0 | 0 | 2 | 16 | 2 | 1 | 4.21 |
| SP | Pfiester, J.Pfiester, Jack † >> | 28 | 1906 | L | 78 | 20 | 20 | 12 | 4 | 3.50 | .281 | 1.17 | 7.1 | 3.4 | 6.1 | 149.1 | 118 | 62 | 58 | 13 | 57 | 101 | 10 | 0 | 0 | 2 | 13 | 0 | 2 | 3.93 |
| SP | Brown, M.Brown, Mordecai # >> | 28 | 1904 | R | 65 | 23 | 21 | 7 | 10 | 4.54 | .298 | 1.27 | 9.0 | 2.5 | 4.9 | 150.2 | 150 | 78 | 76 | 15 | 42 | 81 | 7 | 1 | 0 | 1 | 11 | 0 | 2 | 4.06 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 58 | 0 | 9 | 3 | 4.60 | .307 | 1.30 | 7.1 | 4.7 | 11.4 | 74.1 | 58 | 42 | 38 | 10 | 39 | 94 | 0 | 4 | 1 | 0 | 0 | 2 | 6 | 3.88 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 49 | 0 | 4 | 5 | 2.88 | .323 | 1.40 | 7.9 | 4.7 | 10.7 | 59.1 | 52 | 19 | 19 | 3 | 31 | 70 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 2.97 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 90 | 44 | 0 | 3 | 1 | 3.20 | .275 | 1.14 | 8.0 | 2.3 | 9.6 | 56.1 | 50 | 20 | 20 | 7 | 14 | 60 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.23 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 81 | 35 | 0 | 0 | 0 | 1.46 | .245 | 0.98 | 4.4 | 4.4 | 6.5 | 55.1 | 27 | 9 | 9 | 3 | 27 | 40 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.73 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 50 | 35 | 0 | 1 | 2 | 3.98 | .311 | 1.35 | 8.3 | 4.1 | 9.0 | 40.2 | 37 | 19 | 18 | 5 | 18 | 40 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 3.98 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 64 | 29 | 0 | 1 | 1 | 2.65 | .296 | 1.23 | 7.8 | 3.4 | 7.8 | 37.1 | 32 | 11 | 11 | 5 | 14 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.24 |