| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 31 | 31 | 12 | 8 | 3.73 | .288 | 1.19 | 8.0 | 2.7 | 8.7 | 205.0 | 182 | 87 | 85 | 24 | 62 | 198 | 2 | 0 | 0 | 0 | 17 | 5 | 7 | 3.57 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 30 | 30 | 12 | 11 | 4.61 | .307 | 1.32 | 8.7 | 3.1 | 9.3 | 189.1 | 183 | 100 | 97 | 26 | 66 | 196 | 1 | 0 | 0 | 0 | 18 | 3 | 2 | 3.81 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 84 | 30 | 30 | 14 | 9 | 3.77 | .299 | 1.27 | 8.1 | 3.3 | 6.1 | 224.1 | 201 | 101 | 94 | 32 | 83 | 153 | 11 | 0 | 0 | 0 | 17 | 3 | 2 | 4.64 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 88 | 29 | 29 | 11 | 11 | 5.15 | .338 | 1.49 | 8.8 | 4.6 | 9.0 | 160.2 | 157 | 98 | 92 | 22 | 82 | 160 | 0 | 0 | 0 | 0 | 12 | 7 | 9 | 4.46 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 29 | 29 | 13 | 4 | 4.71 | .315 | 1.37 | 9.4 | 2.9 | 8.3 | 181.2 | 189 | 97 | 95 | 26 | 59 | 166 | 0 | 0 | 0 | 0 | 14 | 3 | 4 | 4.06 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 81 | 0 | 5 | 8 | 4.13 | .302 | 1.27 | 8.2 | 3.2 | 10.1 | 100.1 | 91 | 48 | 46 | 17 | 36 | 112 | 0 | 8 | 5 | 0 | 0 | 3 | 0 | 4.14 |
| RP | Chapman, A.Chapman, Aroldis >> | 24 | 2012 | L | 88 | 79 | 0 | 2 | 4 | 3.65 | .288 | 1.16 | 6.5 | 4.0 | 11.2 | 66.2 | 48 | 28 | 27 | 15 | 29 | 82 | 0 | 10 | 5 | 0 | 0 | 4 | 2 | 4.97 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 63 | 0 | 2 | 6 | 2.98 | .267 | 1.06 | 6.9 | 2.7 | 12.0 | 60.1 | 46 | 22 | 20 | 7 | 18 | 80 | 0 | 13 | 3 | 0 | 0 | 2 | 3 | 2.85 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 26 | 0 | 3 | 2 | 3.38 | .273 | 1.13 | 6.6 | 3.8 | 6.9 | 26.2 | 19 | 13 | 10 | 3 | 11 | 20 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.23 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 22 | 0 | 4 | 1 | 2.31 | .239 | 0.94 | 7.4 | 1.2 | 10.6 | 23.1 | 19 | 7 | 6 | 4 | 3 | 27 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 69 | 18 | 0 | 1 | 0 | 3.86 | .286 | 1.20 | 7.8 | 3.1 | 7.4 | 23.1 | 20 | 11 | 10 | 3 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.09 |