| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 27 | 27 | 12 | 10 | 4.29 | .286 | 1.18 | 8.5 | 2.2 | 6.4 | 182.1 | 171 | 90 | 87 | 24 | 45 | 129 | 6 | 0 | 0 | 0 | 14 | 3 | 5 | 4.09 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 91 | 26 | 26 | 11 | 7 | 4.41 | .294 | 1.21 | 8.2 | 2.8 | 8.7 | 175.1 | 159 | 86 | 86 | 29 | 54 | 169 | 2 | 0 | 0 | 0 | 13 | 6 | 4 | 4.25 |
| SP | Gooden, D.Gooden, Dwight † >> | 21 | 1985 | R | 76 | 25 | 25 | 19 | 3 | 3.63 | .308 | 1.33 | 8.8 | 3.3 | 6.6 | 188.1 | 183 | 81 | 76 | 28 | 68 | 138 | 4 | 0 | 0 | 0 | 14 | 1 | 5 | 4.57 |
| SP | Millwood, K.Millwood, Kevin † >> | 25 | 1999 | R | 70 | 25 | 25 | 14 | 3 | 3.84 | .307 | 1.29 | 8.4 | 3.2 | 6.8 | 164.0 | 153 | 76 | 70 | 21 | 59 | 123 | 1 | 0 | 0 | 0 | 14 | 6 | 2 | 4.35 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 93 | 63 | 0 | 5 | 1 | 3.01 | .263 | 1.03 | 6.2 | 3.2 | 10.6 | 74.2 | 51 | 26 | 25 | 8 | 26 | 87 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 3.23 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 46 | 0 | 1 | 1 | 2.74 | .246 | 0.96 | 6.7 | 2.0 | 7.2 | 46.0 | 34 | 14 | 14 | 7 | 10 | 37 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 4.09 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 84 | 60 | 0 | 4 | 8 | 4.09 | .280 | 1.12 | 8.4 | 1.8 | 8.7 | 61.2 | 57 | 28 | 28 | 11 | 12 | 59 | 0 | 36 | 6 | 0 | 0 | 3 | 1 | 4.15 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 32 | 0 | 1 | 1 | 2.83 | .348 | 1.57 | 9.6 | 4.8 | 11.3 | 28.2 | 30 | 9 | 9 | 1 | 15 | 35 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 2.68 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 32 | 0 | 1 | 1 | 3.92 | .262 | 1.06 | 7.2 | 2.7 | 10.4 | 20.2 | 16 | 9 | 9 | 3 | 6 | 23 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 3.55 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 66 | 28 | 0 | 3 | 2 | 4.05 | .306 | 1.29 | 7.6 | 4.1 | 6.8 | 33.1 | 28 | 15 | 15 | 2 | 15 | 25 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.73 |