| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 98 | 31 | 31 | 9 | 16 | 4.64 | .316 | 1.35 | 9.7 | 2.5 | 8.4 | 209.2 | 225 | 112 | 108 | 26 | 58 | 195 | 5 | 0 | 0 | 1 | 17 | 8 | 8 | 3.70 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 30 | 29 | 10 | 9 | 5.17 | .322 | 1.40 | 9.1 | 3.5 | 7.3 | 195.0 | 197 | 116 | 112 | 33 | 76 | 159 | 5 | 0 | 0 | 1 | 12 | 5 | 3 | 4.82 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 30 | 29 | 9 | 11 | 6.66 | .340 | 1.52 | 10.9 | 2.8 | 9.1 | 169.0 | 205 | 127 | 125 | 38 | 52 | 171 | 3 | 0 | 0 | 0 | 11 | 4 | 2 | 4.89 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 61 | 0 | 5 | 6 | 3.88 | .275 | 1.12 | 7.6 | 2.5 | 10.5 | 65.0 | 55 | 28 | 28 | 10 | 18 | 76 | 0 | 27 | 3 | 0 | 0 | 1 | 0 | 3.54 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 74 | 0 | 8 | 1 | 3.46 | .290 | 1.22 | 7.2 | 3.9 | 10.4 | 83.1 | 66 | 35 | 32 | 5 | 36 | 96 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.77 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 59 | 0 | 3 | 2 | 4.89 | .344 | 1.54 | 10.0 | 3.9 | 10.2 | 70.0 | 78 | 39 | 38 | 9 | 30 | 79 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.79 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 49 | 0 | 5 | 3 | 5.80 | .329 | 1.43 | 9.6 | 3.5 | 11.0 | 49.2 | 52 | 32 | 32 | 11 | 19 | 60 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 4.76 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 36 | 0 | 2 | 0 | 5.97 | .372 | 1.75 | 13.1 | 2.9 | 9.2 | 37.2 | 54 | 25 | 25 | 8 | 12 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.81 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 36 | 0 | 1 | 2 | 3.29 | .261 | 1.04 | 5.5 | 3.8 | 10.6 | 52.0 | 32 | 19 | 19 | 5 | 22 | 61 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.23 |