| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 11 | 7 | 3.28 | .245 | 0.95 | 6.7 | 1.9 | 10.6 | 181.0 | 134 | 67 | 66 | 29 | 38 | 214 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.41 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 88 | 30 | 30 | 11 | 7 | 3.85 | .285 | 1.17 | 7.7 | 2.9 | 6.4 | 154.1 | 131 | 67 | 66 | 23 | 50 | 109 | 0 | 0 | 0 | 0 | 9 | 4 | 1 | 4.58 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 30 | 30 | 7 | 10 | 4.61 | .321 | 1.41 | 9.6 | 3.1 | 9.1 | 181.2 | 194 | 96 | 93 | 21 | 62 | 183 | 2 | 0 | 0 | 0 | 15 | 2 | 2 | 3.55 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 81 | 30 | 30 | 13 | 6 | 5.81 | .320 | 1.40 | 9.9 | 2.7 | 9.0 | 162.2 | 179 | 105 | 105 | 39 | 48 | 162 | 2 | 0 | 0 | 0 | 10 | 3 | 2 | 5.07 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 70 | 0 | 4 | 14 | 4.83 | .301 | 1.26 | 7.6 | 3.8 | 8.3 | 78.1 | 66 | 42 | 42 | 6 | 33 | 72 | 0 | 29 | 7 | 0 | 0 | 2 | 3 | 3.50 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 63 | 0 | 3 | 4 | 3.21 | .258 | 1.03 | 5.7 | 3.7 | 9.6 | 81.1 | 51 | 29 | 29 | 12 | 33 | 86 | 0 | 7 | 8 | 0 | 0 | 1 | 1 | 4.06 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 79 | 0 | 4 | 2 | 3.50 | .292 | 1.19 | 6.5 | 4.3 | 9.6 | 115.2 | 83 | 47 | 45 | 17 | 55 | 123 | 0 | 1 | 1 | 0 | 0 | 5 | 2 | 4.35 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 68 | 0 | 2 | 1 | 2.57 | .264 | 1.05 | 5.3 | 4.3 | 10.9 | 80.2 | 47 | 25 | 23 | 12 | 38 | 97 | 0 | 3 | 1 | 0 | 0 | 2 | 5 | 4.03 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 55 | 0 | 3 | 0 | 3.09 | .267 | 1.06 | 6.8 | 2.8 | 10.4 | 64.0 | 48 | 22 | 22 | 8 | 20 | 74 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.34 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 21 | 2 | 7 | 4 | 5.83 | .362 | 1.68 | 10.0 | 5.3 | 8.0 | 46.1 | 51 | 32 | 30 | 9 | 27 | 41 | 0 | 2 | 0 | 0 | 1 | 1 | 0 | 5.59 |