| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 9 | 13 | 4.35 | .292 | 1.22 | 8.6 | 2.4 | 9.8 | 163.1 | 156 | 81 | 79 | 28 | 43 | 178 | 0 | 0 | 0 | 0 | 18 | 3 | 0 | 3.90 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 26 | 26 | 7 | 11 | 5.69 | .324 | 1.42 | 9.1 | 3.7 | 9.9 | 159.2 | 161 | 105 | 101 | 36 | 65 | 175 | 1 | 0 | 0 | 0 | 9 | 4 | 5 | 5.04 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 26 | 26 | 13 | 12 | 3.78 | .330 | 1.45 | 7.9 | 5.1 | 9.4 | 157.0 | 138 | 74 | 66 | 19 | 89 | 164 | 0 | 0 | 0 | 0 | 13 | 5 | 3 | 4.28 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 83 | 72 | 0 | 6 | 3 | 3.35 | .273 | 1.10 | 6.3 | 3.7 | 10.1 | 83.1 | 58 | 34 | 31 | 12 | 34 | 93 | 0 | 0 | 4 | 0 | 0 | 2 | 7 | 3.94 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 53 | 0 | 4 | 3 | 5.63 | .323 | 1.41 | 9.8 | 2.9 | 9.5 | 56.0 | 61 | 36 | 35 | 13 | 18 | 59 | 0 | 1 | 4 | 0 | 0 | 1 | 4 | 4.93 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 40 | 0 | 1 | 0 | 4.97 | .352 | 1.61 | 9.7 | 5.0 | 11.9 | 41.2 | 44 | 24 | 23 | 6 | 23 | 54 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.02 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 66 | 20 | 0 | 0 | 3 | 5.50 | .316 | 1.37 | 10.2 | 2.3 | 9.7 | 86.2 | 97 | 54 | 53 | 18 | 22 | 93 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.36 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 5 | 0 | 0 | 3 | 16.20 | .630 | 5.10 | 33.0 | 18.0 | 9.0 | 3.1 | 11 | 6 | 6 | 1 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.33 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 54 | 0 | 3 | 4 | 1.83 | .272 | 1.08 | 6.7 | 3.1 | 10.4 | 59.0 | 44 | 12 | 12 | 5 | 20 | 68 | 0 | 34 | 1 | 0 | 0 | 2 | 1 | 2.92 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 46 | 0 | 0 | 0 | 3.97 | .338 | 1.49 | 8.4 | 5.2 | 11.3 | 47.2 | 44 | 22 | 21 | 9 | 27 | 59 | 0 | 4 | 6 | 0 | 0 | 2 | 1 | 4.83 |