| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 98 | 23 | 23 | 11 | 7 | 4.21 | .296 | 1.25 | 8.7 | 2.5 | 5.9 | 173.0 | 167 | 88 | 81 | 19 | 49 | 113 | 2 | 0 | 0 | 0 | 11 | 2 | 1 | 4.01 |
| SP | Hubbell, C.Hubbell, Carl † >> | 33 | 1936 | L | 85 | 23 | 23 | 14 | 4 | 3.36 | .298 | 1.27 | 8.6 | 2.8 | 3.8 | 176.2 | 169 | 78 | 66 | 16 | 55 | 74 | 4 | 0 | 0 | 2 | 14 | 1 | 3 | 4.30 |
| SP | Kluber, C.Kluber, Corey # >> | 28 | 2014 | R | 89 | 22 | 22 | 13 | 7 | 3.79 | .300 | 1.27 | 9.2 | 2.2 | 8.7 | 161.2 | 165 | 73 | 68 | 11 | 40 | 155 | 3 | 0 | 0 | 1 | 14 | 3 | 3 | 2.76 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 99 | 46 | 0 | 3 | 1 | 1.93 | .300 | 1.25 | 5.5 | 5.8 | 5.1 | 28.0 | 17 | 6 | 6 | 1 | 18 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.36 |
| RP | Assenmacher, P.Assenmacher, Paul >> | 31 | 1991 | L | 73 | 39 | 0 | 1 | 0 | 1.14 | .184 | 0.68 | 3.9 | 2.3 | 9.8 | 23.2 | 10 | 6 | 3 | 0 | 6 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.61 |
| RP | Jackson, L.Jackson, Luke >> | 29 | 2021 | R | 79 | 7 | 0 | 1 | 0 | 1.69 | .273 | 1.13 | 5.4 | 5.4 | 12.6 | 5.1 | 3 | 1 | 1 | 1 | 3 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.60 |
| SP | Peters, G.Peters, Gary >> | 26 | 1963 | L | 94 | 4 | 0 | 1 | 0 | 1.42 | .208 | 0.79 | 7.5 | 0.0 | 1.5 | 6.1 | 5 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.83 |
| RP | Lavelle, G.Lavelle, Gary >> | 33 | 1982 | L | 47 | 24 | 0 | 4 | 1 | 3.06 | .338 | 1.53 | 11.1 | 3.2 | 6.9 | 17.2 | 21 | 6 | 6 | 0 | 6 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.53 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 100 | 37 | 0 | 1 | 2 | 2.29 | .276 | 1.14 | 7.2 | 3.2 | 8.1 | 39.1 | 31 | 10 | 10 | 4 | 14 | 35 | 0 | 31 | 4 | 0 | 0 | 0 | 1 | 3.62 |