| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 98 | 36 | 36 | 20 | 9 | 4.17 | .296 | 1.25 | 8.8 | 2.4 | 5.7 | 276.1 | 270 | 138 | 128 | 27 | 75 | 175 | 4 | 0 | 0 | 0 | 18 | 3 | 6 | 3.85 |
| SP | Hubbell, C.Hubbell, Carl † >> | 33 | 1936 | L | 85 | 35 | 35 | 21 | 9 | 3.66 | .306 | 1.32 | 9.2 | 2.6 | 4.4 | 265.1 | 272 | 126 | 108 | 28 | 78 | 129 | 6 | 0 | 0 | 3 | 20 | 1 | 4 | 4.29 |
| SP | Kluber, C.Kluber, Corey # >> | 28 | 2014 | R | 89 | 35 | 35 | 20 | 9 | 3.27 | .295 | 1.23 | 8.7 | 2.5 | 8.4 | 258.1 | 248 | 107 | 94 | 19 | 71 | 240 | 6 | 0 | 0 | 2 | 23 | 5 | 4 | 2.98 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 99 | 71 | 0 | 5 | 2 | 1.56 | .261 | 1.04 | 4.3 | 5.0 | 5.4 | 52.0 | 25 | 9 | 9 | 1 | 29 | 31 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.79 |
| RP | Assenmacher, P.Assenmacher, Paul >> | 31 | 1991 | L | 73 | 59 | 0 | 1 | 0 | 0.99 | .199 | 0.74 | 4.8 | 2.0 | 9.5 | 36.1 | 19 | 7 | 4 | 0 | 8 | 38 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1.56 |
| RP | Jackson, L.Jackson, Luke >> | 29 | 2021 | R | 79 | 15 | 0 | 3 | 1 | 3.00 | .250 | 1.00 | 3.8 | 5.3 | 7.5 | 12.0 | 5 | 4 | 4 | 3 | 7 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.33 |
| SP | Peters, G.Peters, Gary >> | 26 | 1963 | L | 94 | 8 | 0 | 1 | 0 | 3.32 | .316 | 1.38 | 11.6 | 1.3 | 3.0 | 21.2 | 27 | 8 | 8 | 1 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Lavelle, G.Lavelle, Gary >> | 33 | 1982 | L | 47 | 32 | 0 | 5 | 1 | 2.82 | .337 | 1.52 | 11.0 | 2.9 | 6.5 | 22.1 | 27 | 8 | 7 | 1 | 7 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.09 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 100 | 50 | 0 | 1 | 4 | 3.19 | .271 | 1.12 | 7.0 | 3.2 | 8.7 | 53.2 | 41 | 19 | 19 | 6 | 19 | 51 | 0 | 41 | 7 | 0 | 0 | 0 | 1 | 3.62 |