| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 98 | 41 | 41 | 24 | 9 | 3.94 | .290 | 1.21 | 8.6 | 2.3 | 5.8 | 315.1 | 301 | 149 | 138 | 29 | 82 | 202 | 5 | 0 | 0 | 0 | 22 | 3 | 8 | 3.72 |
| SP | Hubbell, C.Hubbell, Carl † >> | 33 | 1936 | L | 85 | 41 | 41 | 23 | 12 | 3.80 | .309 | 1.34 | 9.3 | 2.7 | 4.3 | 310.0 | 322 | 151 | 131 | 30 | 92 | 147 | 7 | 0 | 0 | 4 | 22 | 2 | 5 | 4.22 |
| SP | Kluber, C.Kluber, Corey # >> | 28 | 2014 | R | 89 | 40 | 40 | 24 | 10 | 3.19 | .291 | 1.21 | 8.5 | 2.4 | 8.3 | 299.1 | 282 | 119 | 106 | 21 | 79 | 276 | 9 | 0 | 0 | 3 | 27 | 7 | 5 | 2.93 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 99 | 82 | 0 | 5 | 2 | 1.82 | .261 | 1.04 | 4.7 | 4.7 | 5.8 | 59.1 | 31 | 13 | 12 | 1 | 31 | 38 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.56 |
| RP | Assenmacher, P.Assenmacher, Paul >> | 31 | 1991 | L | 73 | 70 | 0 | 2 | 0 | 1.07 | .203 | 0.76 | 4.9 | 1.9 | 9.9 | 42.0 | 23 | 8 | 5 | 0 | 9 | 46 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1.45 |
| RP | Jackson, L.Jackson, Luke >> | 29 | 2021 | R | 79 | 17 | 0 | 3 | 3 | 4.30 | .290 | 1.23 | 5.1 | 6.4 | 7.1 | 14.2 | 8 | 7 | 7 | 3 | 10 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.36 |
| SP | Peters, G.Peters, Gary >> | 26 | 1963 | L | 94 | 8 | 0 | 1 | 0 | 3.32 | .316 | 1.38 | 11.6 | 1.3 | 3.0 | 21.2 | 27 | 8 | 8 | 1 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Lavelle, G.Lavelle, Gary >> | 33 | 1982 | L | 47 | 39 | 0 | 7 | 1 | 3.51 | .336 | 1.52 | 11.5 | 2.5 | 6.1 | 25.2 | 32 | 11 | 10 | 2 | 7 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 100 | 57 | 0 | 1 | 4 | 3.18 | .278 | 1.16 | 7.1 | 3.3 | 8.6 | 62.1 | 49 | 22 | 22 | 7 | 23 | 59 | 0 | 46 | 8 | 0 | 0 | 0 | 1 | 3.68 |