| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 13 | 13 | 5 | 5 | 4.89 | .328 | 1.40 | 9.9 | 2.7 | 5.3 | 77.1 | 85 | 48 | 42 | 15 | 23 | 45 | 0 | 0 | 0 | 0 | 7 | 5 | 0 | 5.45 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 13 | 13 | 4 | 7 | 5.42 | .305 | 1.28 | 9.0 | 2.6 | 8.4 | 81.1 | 81 | 51 | 49 | 18 | 23 | 76 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.98 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 13 | 13 | 5 | 6 | 7.04 | .364 | 1.71 | 12.1 | 3.3 | 4.5 | 70.1 | 94 | 55 | 55 | 16 | 26 | 35 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 6.13 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 75 | 39 | 0 | 1 | 1 | 2.74 | .278 | 1.11 | 5.7 | 4.4 | 10.5 | 49.1 | 31 | 15 | 15 | 8 | 24 | 57 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 4.39 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 18 | 0 | 1 | 1 | 4.76 | .301 | 1.29 | 10.1 | 1.6 | 6.4 | 17.0 | 19 | 9 | 9 | 3 | 3 | 12 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 45 | 12 | 0 | 0 | 1 | 2.19 | .229 | 0.89 | 4.5 | 3.8 | 4.5 | 12.1 | 6 | 3 | 3 | 2 | 5 | 6 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.42 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 44 | 10 | 0 | 0 | 0 | 7.15 | .393 | 1.85 | 14.7 | 2.5 | 6.5 | 11.1 | 18 | 9 | 9 | 3 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.18 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 46 | 2 | 0 | 0 | 1 | 15.19 | .484 | 2.81 | 19.8 | 7.2 | 7.2 | 5.1 | 11 | 11 | 9 | 1 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.40 |