| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 25 | 25 | 13 | 7 | 4.17 | .307 | 1.32 | 8.4 | 3.5 | 9.3 | 174.2 | 163 | 84 | 81 | 23 | 67 | 180 | 4 | 0 | 0 | 2 | 12 | 2 | 3 | 3.84 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 73 | 24 | 24 | 8 | 8 | 5.56 | .351 | 1.59 | 10.4 | 3.9 | 7.3 | 136.0 | 157 | 89 | 84 | 28 | 59 | 110 | 0 | 0 | 0 | 0 | 7 | 5 | 0 | 5.47 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 24 | 24 | 5 | 15 | 6.33 | .381 | 1.80 | 12.1 | 4.2 | 7.1 | 140.2 | 188 | 114 | 99 | 28 | 65 | 111 | 2 | 0 | 0 | 0 | 8 | 7 | 5 | 5.56 |
| SP | Santana, E.Santana, Ervin # >> | 25 | 2008 | R | 55 | 24 | 23 | 10 | 6 | 4.37 | .306 | 1.30 | 9.5 | 2.3 | 8.3 | 150.1 | 158 | 79 | 73 | 20 | 38 | 139 | 3 | 0 | 0 | 2 | 12 | 3 | 2 | 3.70 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 91 | 57 | 0 | 4 | 3 | 1.45 | .273 | 1.11 | 5.4 | 4.6 | 9.4 | 62.0 | 37 | 15 | 10 | 3 | 32 | 65 | 0 | 8 | 5 | 0 | 0 | 1 | 1 | 3.13 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 53 | 0 | 1 | 4 | 3.03 | .249 | 0.96 | 6.1 | 2.6 | 9.1 | 62.1 | 42 | 21 | 21 | 8 | 18 | 63 | 0 | 9 | 1 | 0 | 0 | 2 | 2 | 3.61 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 34 | 0 | 3 | 2 | 4.22 | .314 | 1.38 | 9.3 | 3.1 | 9.3 | 32.0 | 33 | 15 | 15 | 6 | 11 | 33 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 56 | 72 | 0 | 2 | 3 | 4.04 | .300 | 1.24 | 7.9 | 3.3 | 8.3 | 49.0 | 43 | 23 | 22 | 8 | 18 | 45 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.51 |
| RP | Kim, B.Kim, Byung-Hyun >> | 23 | 2002 | R | 37 | 27 | 0 | 0 | 0 | 5.12 | .321 | 1.39 | 9.9 | 2.9 | 10.7 | 31.2 | 34 | 18 | 18 | 5 | 10 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.77 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 10 | 0 | 3 | 0 | 2.08 | .291 | 1.23 | 7.6 | 3.5 | 7.6 | 13.0 | 11 | 3 | 3 | 2 | 5 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.46 |