| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 16 | 16 | 5 | 5 | 4.57 | .343 | 1.50 | 10.9 | 2.7 | 9.5 | 100.1 | 121 | 53 | 51 | 10 | 30 | 106 | 0 | 0 | 0 | 0 | 10 | 6 | 1 | 3.26 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 15 | 15 | 4 | 7 | 5.09 | .289 | 1.18 | 7.6 | 3.1 | 9.2 | 81.1 | 68 | 49 | 46 | 17 | 28 | 83 | 1 | 0 | 0 | 0 | 7 | 3 | 2 | 4.83 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 15 | 15 | 1 | 5 | 6.00 | .359 | 1.64 | 11.5 | 3.3 | 7.3 | 69.0 | 88 | 50 | 46 | 9 | 25 | 56 | 1 | 0 | 0 | 0 | 4 | 3 | 3 | 4.29 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 15 | 15 | 2 | 4 | 7.20 | .381 | 1.83 | 12.7 | 3.7 | 7.5 | 70.0 | 99 | 58 | 56 | 20 | 29 | 58 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 6.34 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 54 | 17 | 15 | 3 | 10 | 7.23 | .363 | 1.65 | 11.3 | 3.5 | 7.0 | 66.0 | 83 | 54 | 53 | 17 | 26 | 51 | 1 | 1 | 0 | 0 | 3 | 4 | 3 | 6.17 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 43 | 0 | 4 | 2 | 4.30 | .280 | 1.15 | 7.8 | 2.6 | 10.7 | 52.1 | 45 | 28 | 25 | 9 | 15 | 62 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.79 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 36 | 0 | 2 | 1 | 2.92 | .299 | 1.24 | 7.7 | 3.5 | 5.5 | 49.1 | 42 | 21 | 16 | 6 | 19 | 30 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 4.65 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 36 | 0 | 1 | 3 | 3.06 | .284 | 1.19 | 8.6 | 2.1 | 8.4 | 47.0 | 45 | 21 | 16 | 7 | 11 | 44 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 3.77 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 49 | 28 | 0 | 2 | 1 | 2.95 | .270 | 1.08 | 8.1 | 1.8 | 8.3 | 39.2 | 35 | 14 | 13 | 6 | 8 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.85 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 38 | 27 | 0 | 4 | 1 | 3.00 | .261 | 1.03 | 5.7 | 3.5 | 9.5 | 33.0 | 21 | 11 | 11 | 1 | 13 | 35 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 2.55 |