| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 16 | 16 | 1 | 9 | 6.44 | .387 | 1.87 | 13.4 | 3.5 | 9.1 | 64.1 | 95 | 54 | 46 | 12 | 25 | 65 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 4.67 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 15 | 15 | 2 | 9 | 8.34 | .404 | 1.98 | 13.8 | 4.2 | 6.8 | 77.2 | 118 | 73 | 72 | 19 | 36 | 58 | 0 | 0 | 0 | 0 | 3 | 4 | 1 | 6.26 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 53 | 15 | 15 | 3 | 7 | 7.38 | .357 | 1.62 | 11.7 | 3.0 | 6.2 | 81.2 | 105 | 69 | 67 | 18 | 27 | 56 | 0 | 0 | 0 | 0 | 3 | 4 | 1 | 5.65 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 51 | 15 | 15 | 3 | 7 | 5.63 | .352 | 1.63 | 11.8 | 3.0 | 7.1 | 84.2 | 110 | 56 | 53 | 14 | 28 | 66 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 4.60 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 39 | 0 | 6 | 2 | 4.19 | .275 | 1.12 | 6.8 | 3.3 | 10.1 | 58.0 | 44 | 28 | 27 | 9 | 21 | 65 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 3.91 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 38 | 0 | 3 | 2 | 2.63 | .271 | 1.12 | 8.2 | 2.0 | 9.3 | 54.2 | 49 | 16 | 16 | 6 | 12 | 56 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.04 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 32 | 0 | 3 | 1 | 4.34 | .337 | 1.50 | 10.7 | 2.9 | 12.2 | 37.1 | 44 | 20 | 18 | 7 | 12 | 50 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.81 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 34 | 24 | 0 | 0 | 1 | 3.67 | .314 | 1.33 | 7.3 | 4.7 | 7.3 | 27.0 | 22 | 11 | 11 | 5 | 14 | 22 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 5.44 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 41 | 7 | 0 | 0 | 2 | 3.12 | .333 | 1.38 | 4.5 | 9.0 | 11.3 | 8.2 | 4 | 3 | 3 | 1 | 8 | 10 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.50 |