| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 14 | 14 | 5 | 6 | 3.53 | .268 | 1.07 | 7.5 | 2.2 | 9.4 | 104.2 | 87 | 41 | 41 | 22 | 25 | 109 | 3 | 0 | 0 | 1 | 9 | 3 | 3 | 4.46 |
| SP | Sheets, B.Sheets, Ben # >> | 26 | 2004 | R | 90 | 14 | 14 | 4 | 4 | 3.57 | .286 | 1.14 | 8.6 | 1.7 | 10.9 | 88.1 | 84 | 35 | 35 | 13 | 17 | 107 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 3.24 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 13 | 13 | 2 | 3 | 3.67 | .256 | 1.01 | 6.3 | 2.9 | 5.3 | 56.1 | 39 | 23 | 23 | 6 | 18 | 33 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.23 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 54 | 15 | 13 | 3 | 7 | 5.77 | .310 | 1.29 | 9.5 | 2.2 | 7.0 | 78.0 | 82 | 50 | 50 | 14 | 19 | 61 | 1 | 0 | 0 | 0 | 4 | 4 | 2 | 4.65 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 35 | 0 | 3 | 2 | 3.32 | .278 | 1.16 | 6.8 | 3.8 | 8.8 | 40.2 | 30 | 15 | 15 | 5 | 17 | 39 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 3.95 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 34 | 0 | 1 | 3 | 3.16 | .274 | 1.11 | 8.6 | 1.4 | 9.4 | 51.1 | 49 | 18 | 18 | 11 | 8 | 53 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.25 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 28 | 0 | 3 | 0 | 2.95 | .281 | 1.15 | 6.2 | 4.3 | 8.4 | 42.2 | 29 | 14 | 14 | 2 | 20 | 39 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.26 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 24 | 0 | 4 | 3 | 5.46 | .317 | 1.39 | 9.3 | 3.2 | 8.0 | 28.0 | 29 | 17 | 17 | 9 | 10 | 25 | 0 | 2 | 3 | 0 | 0 | 0 | 3 | 6.46 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 18 | 0 | 2 | 1 | 3.13 | .289 | 1.17 | 6.3 | 4.3 | 6.7 | 23.0 | 16 | 10 | 8 | 6 | 11 | 17 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 6.48 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 38 | 12 | 0 | 1 | 0 | 4.85 | .409 | 2.08 | 10.4 | 8.3 | 8.3 | 13.0 | 15 | 7 | 7 | 3 | 12 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.92 |