| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 15 | 15 | 3 | 7 | 6.60 | .355 | 1.61 | 10.4 | 4.1 | 8.8 | 75.0 | 87 | 55 | 55 | 14 | 34 | 73 | 2 | 0 | 0 | 1 | 4 | 3 | 2 | 4.96 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 15 | 15 | 5 | 3 | 5.35 | .320 | 1.41 | 8.7 | 4.0 | 9.0 | 67.1 | 65 | 42 | 40 | 12 | 30 | 67 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 4.67 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 78 | 15 | 15 | 5 | 3 | 4.74 | .325 | 1.41 | 10.3 | 2.5 | 5.7 | 79.2 | 90 | 46 | 42 | 16 | 22 | 50 | 1 | 0 | 0 | 0 | 6 | 3 | 0 | 5.32 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 14 | 13 | 6 | 4 | 5.47 | .319 | 1.36 | 10.0 | 2.3 | 5.4 | 74.0 | 82 | 48 | 45 | 14 | 19 | 44 | 0 | 0 | 1 | 0 | 5 | 3 | 0 | 5.16 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 15 | 13 | 0 | 9 | 7.97 | .373 | 1.77 | 13.2 | 2.9 | 5.6 | 66.2 | 97 | 59 | 59 | 15 | 21 | 41 | 0 | 1 | 0 | 0 | 2 | 1 | 3 | 5.71 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 38 | 0 | 4 | 2 | 4.79 | .347 | 1.55 | 10.1 | 3.8 | 9.4 | 47.0 | 53 | 25 | 25 | 6 | 20 | 49 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.98 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 38 | 0 | 2 | 2 | 3.09 | .297 | 1.27 | 7.9 | 3.6 | 10.0 | 55.1 | 48 | 19 | 19 | 3 | 22 | 61 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 2.69 |
| RP | Dotel, O.Dotel, Octavio # >> | 29 | 2002 | R | 88 | 43 | 0 | 1 | 2 | 4.45 | .292 | 1.22 | 7.9 | 3.2 | 10.1 | 56.2 | 49 | 28 | 28 | 12 | 20 | 63 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 4.66 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 24 | 0 | 4 | 4 | 5.26 | .377 | 1.81 | 10.1 | 6.4 | 7.9 | 49.2 | 55 | 30 | 29 | 6 | 35 | 43 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.98 |