| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 25 | 25 | 10 | 5 | 3.93 | .280 | 1.13 | 7.8 | 2.4 | 9.7 | 162.2 | 140 | 71 | 71 | 22 | 44 | 175 | 4 | 0 | 0 | 2 | 13 | 6 | 1 | 3.53 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 87 | 24 | 24 | 9 | 7 | 4.15 | .296 | 1.24 | 8.4 | 2.8 | 9.2 | 145.1 | 135 | 68 | 67 | 18 | 45 | 148 | 1 | 0 | 0 | 0 | 12 | 3 | 2 | 3.57 |
| SP | Perez, O.Perez, Odalis † >> | 25 | 2002 | L | 82 | 23 | 23 | 14 | 2 | 3.32 | .277 | 1.09 | 8.2 | 1.6 | 6.0 | 149.0 | 136 | 57 | 55 | 24 | 26 | 100 | 1 | 0 | 0 | 0 | 15 | 9 | 1 | 4.46 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 68 | 24 | 24 | 11 | 2 | 5.02 | .330 | 1.43 | 9.9 | 3.0 | 7.1 | 122.0 | 134 | 70 | 68 | 22 | 40 | 96 | 1 | 0 | 0 | 0 | 11 | 6 | 3 | 4.90 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 60 | 0 | 4 | 3 | 2.76 | .297 | 1.23 | 5.7 | 5.5 | 9.3 | 71.2 | 45 | 26 | 22 | 5 | 43 | 73 | 0 | 2 | 3 | 0 | 0 | 3 | 2 | 3.80 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 56 | 0 | 4 | 4 | 4.44 | .283 | 1.17 | 7.5 | 3.0 | 6.3 | 71.0 | 59 | 35 | 35 | 16 | 24 | 50 | 0 | 7 | 4 | 0 | 0 | 1 | 5 | 5.58 |
| RP | Aceves, A.Aceves, Alfredo >> | 27 | 2009 | R | 30 | 22 | 0 | 3 | 4 | 6.14 | .353 | 1.59 | 10.2 | 4.1 | 3.7 | 22.0 | 25 | 15 | 15 | 5 | 10 | 9 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 6.64 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 54 | 0 | 4 | 4 | 5.34 | .307 | 1.27 | 9.0 | 2.4 | 9.1 | 64.0 | 64 | 38 | 38 | 10 | 17 | 65 | 0 | 6 | 7 | 0 | 0 | 4 | 9 | 3.98 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 41 | 15 | 1 | 1 | 2 | 5.26 | .343 | 1.49 | 8.5 | 4.9 | 6.6 | 53.0 | 50 | 31 | 31 | 10 | 29 | 39 | 0 | 1 | 0 | 0 | 0 | 4 | 1 | 5.85 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 30 | 2002 | R | 40 | 17 | 0 | 0 | 1 | 4.32 | .286 | 1.20 | 8.4 | 2.8 | 3.9 | 16.2 | 15 | 8 | 8 | 5 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 7.13 |