| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 16 | 16 | 9 | 6 | 3.15 | .261 | 1.05 | 8.1 | 1.4 | 9.6 | 105.2 | 95 | 38 | 37 | 11 | 16 | 112 | 6 | 0 | 0 | 2 | 11 | 1 | 2 | 2.71 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 85 | 15 | 15 | 7 | 2 | 3.73 | .271 | 1.10 | 8.1 | 1.8 | 6.5 | 101.1 | 91 | 46 | 42 | 15 | 20 | 73 | 2 | 0 | 0 | 1 | 8 | 2 | 2 | 4.14 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 15 | 15 | 6 | 5 | 5.54 | .334 | 1.48 | 10.7 | 2.7 | 7.1 | 79.2 | 94 | 49 | 49 | 12 | 24 | 62 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.39 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 16 | 15 | 8 | 5 | 4.50 | .326 | 1.44 | 9.8 | 3.1 | 5.8 | 96.0 | 105 | 48 | 48 | 12 | 33 | 62 | 0 | 0 | 0 | 0 | 9 | 1 | 3 | 4.40 |
| SP | Oswalt, R.Oswalt, Roy # >> | 24 | 2001 | R | 72 | 15 | 15 | 5 | 5 | 4.40 | .283 | 1.17 | 9.4 | 1.3 | 7.7 | 77.2 | 80 | 38 | 38 | 12 | 11 | 66 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 3.78 |
| SU | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 33 | 0 | 1 | 2 | 4.59 | .329 | 1.44 | 9.8 | 3.3 | 9.0 | 33.1 | 36 | 22 | 17 | 3 | 12 | 33 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 3.36 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 37 | 0 | 2 | 0 | 5.45 | .305 | 1.29 | 8.5 | 3.1 | 8.3 | 38.0 | 36 | 23 | 23 | 5 | 13 | 35 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 3.97 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 24 | 0 | 1 | 0 | 5.48 | .343 | 1.57 | 8.6 | 5.5 | 10.6 | 23.0 | 22 | 14 | 14 | 2 | 14 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.61 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 11 | 0 | 2 | 0 | 2.54 | .333 | 1.43 | 7.8 | 5.1 | 6.3 | 46.0 | 40 | 13 | 13 | 4 | 26 | 32 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.63 |