| SP | Webb, B.Webb, Brandon # >> | 24 | 2003 | R | 64 | 35 | 35 | 14 | 11 | 4.33 | .306 | 1.28 | 8.3 | 3.3 | 7.7 | 224.1 | 206 | 109 | 108 | 30 | 82 | 192 | 0 | 0 | 0 | 0 | 25 | 9 | 10 | 4.25 |
| SP | Burnett, A.Burnett, A.J. † # >> | 25 | 2002 | R | 57 | 33 | 33 | 17 | 10 | 4.44 | .300 | 1.25 | 7.3 | 4.0 | 7.9 | 216.2 | 176 | 107 | 107 | 29 | 95 | 189 | 0 | 0 | 0 | 0 | 17 | 7 | 15 | 4.41 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 16 | 8 | 6 | 3 | 4.46 | .339 | 1.51 | 7.9 | 5.8 | 6.9 | 76.2 | 67 | 42 | 38 | 9 | 49 | 58 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 5.03 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 32 | 31 | 13 | 11 | 4.99 | .338 | 1.51 | 8.6 | 5.0 | 6.3 | 191.1 | 182 | 107 | 106 | 35 | 107 | 133 | 0 | 0 | 0 | 0 | 16 | 4 | 3 | 5.73 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 87 | 0 | 3 | 1 | 2.94 | .261 | 1.04 | 6.1 | 3.4 | 8.3 | 110.1 | 74 | 36 | 36 | 8 | 41 | 102 | 0 | 5 | 4 | 0 | 0 | 2 | 1 | 3.26 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 68 | 0 | 11 | 3 | 3.47 | .297 | 1.24 | 7.1 | 4.2 | 10.6 | 80.1 | 63 | 33 | 31 | 5 | 37 | 94 | 0 | 14 | 6 | 0 | 0 | 2 | 4 | 2.93 |
| RP | Remlinger, M.Remlinger, Mike >> | 36 | 2002 | L | 35 | 29 | 0 | 3 | 3 | 3.41 | .299 | 1.25 | 8.2 | 3.2 | 8.7 | 34.1 | 31 | 13 | 13 | 5 | 12 | 33 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 4.12 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 70 | 0 | 4 | 5 | 4.24 | .313 | 1.35 | 7.4 | 4.8 | 9.8 | 85.0 | 70 | 40 | 40 | 13 | 45 | 93 | 0 | 10 | 3 | 0 | 0 | 1 | 2 | 4.42 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 26 | 23 | 0 | 1 | 1 | 1.42 | .329 | 1.37 | 6.2 | 6.2 | 11.4 | 19.0 | 13 | 3 | 3 | 0 | 13 | 24 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 2.84 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 29 | 0 | 0 | 1 | 3.28 | .362 | 1.70 | 7.1 | 8.6 | 7.1 | 24.2 | 19 | 9 | 9 | 1 | 23 | 19 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.83 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 4 | 0 | 0 | 0 | 7.36 | .389 | 1.91 | 14.1 | 3.9 | 6.4 | 14.2 | 22 | 12 | 12 | 2 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.71 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 55 | 31 | 25 | 10 | 9 | 5.89 | .351 | 1.58 | 8.6 | 5.6 | 9.1 | 174.1 | 167 | 119 | 114 | 29 | 109 | 176 | 0 | 0 | 0 | 0 | 12 | 7 | 6 | 5.14 |