| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 95 | 17 | 17 | 5 | 6 | 4.10 | .307 | 1.32 | 8.8 | 3.0 | 9.3 | 101.0 | 99 | 48 | 46 | 14 | 34 | 104 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 3.78 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 73 | 17 | 17 | 3 | 10 | 5.97 | .353 | 1.64 | 11.8 | 2.9 | 10.2 | 86.0 | 113 | 57 | 57 | 12 | 28 | 97 | 0 | 0 | 0 | 0 | 6 | 0 | 2 | 3.53 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 75 | 17 | 17 | 6 | 6 | 3.70 | .288 | 1.20 | 8.2 | 2.5 | 8.3 | 107.0 | 98 | 47 | 44 | 12 | 30 | 99 | 3 | 0 | 0 | 1 | 10 | 2 | 3 | 3.50 |
| SP | Verlander, J.Verlander, Justin >> | 33 | 2016 | R | 55 | 17 | 17 | 6 | 7 | 4.93 | .324 | 1.37 | 9.5 | 2.9 | 9.2 | 96.2 | 101 | 55 | 53 | 13 | 31 | 98 | 2 | 0 | 0 | 0 | 8 | 7 | 1 | 3.91 |
| SP | Sanchez, A.Sanchez, Anibal >> | 29 | 2013 | R | 28 | 13 | 8 | 1 | 6 | 7.22 | .405 | 2.04 | 12.5 | 6.1 | 9.9 | 52.1 | 72 | 43 | 42 | 13 | 35 | 57 | 0 | 0 | 1 | 0 | 2 | 0 | 2 | 6.08 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 85 | 53 | 0 | 2 | 0 | 1.51 | .226 | 0.88 | 5.9 | 2.0 | 8.5 | 53.2 | 35 | 12 | 9 | 2 | 12 | 50 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.28 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 60 | 47 | 0 | 0 | 1 | 4.89 | .317 | 1.39 | 7.6 | 4.9 | 5.5 | 46.0 | 39 | 26 | 25 | 8 | 25 | 28 | 0 | 3 | 1 | 0 | 0 | 0 | 5 | 5.67 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 72 | 51 | 0 | 2 | 2 | 3.16 | .314 | 1.37 | 6.1 | 6.4 | 11.0 | 31.1 | 21 | 11 | 11 | 2 | 22 | 38 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 26 | 38 | 0 | 3 | 2 | 2.97 | .281 | 1.14 | 8.7 | 1.6 | 7.4 | 33.1 | 32 | 11 | 11 | 2 | 6 | 27 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.79 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 47 | 39 | 0 | 3 | 0 | 3.41 | .307 | 1.33 | 7.0 | 5.2 | 10.2 | 31.2 | 24 | 12 | 12 | 2 | 18 | 35 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.32 |