| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 82 | 28 | 28 | 10 | 11 | 4.66 | .316 | 1.34 | 9.0 | 3.0 | 5.3 | 183.1 | 184 | 104 | 95 | 23 | 62 | 108 | 4 | 0 | 0 | 0 | 13 | 8 | 2 | 4.60 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 71 | 27 | 27 | 6 | 8 | 4.49 | .323 | 1.39 | 8.0 | 4.6 | 4.1 | 166.1 | 147 | 98 | 83 | 14 | 85 | 75 | 0 | 0 | 0 | 0 | 15 | 6 | 0 | 4.84 |
| SP | Lundgren, C.Lundgren, Carl # >> | 27 | 1907 | R | 55 | 27 | 27 | 13 | 8 | 4.81 | .324 | 1.41 | 7.6 | 5.1 | 4.3 | 170.1 | 144 | 104 | 91 | 18 | 97 | 81 | 4 | 0 | 0 | 1 | 11 | 4 | 8 | 5.21 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 50 | 27 | 27 | 5 | 12 | 5.47 | .331 | 1.45 | 10.0 | 3.1 | 5.6 | 130.0 | 144 | 93 | 79 | 25 | 45 | 81 | 1 | 0 | 0 | 0 | 13 | 4 | 2 | 5.38 |
| SP | Arrieta, J.Arrieta, Jake # >> | 30 | 2016 | R | 43 | 16 | 14 | 5 | 4 | 5.64 | .373 | 1.77 | 10.1 | 5.9 | 7.4 | 75.0 | 84 | 56 | 47 | 12 | 49 | 62 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 5.43 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 99 | 83 | 0 | 5 | 2 | 3.69 | .324 | 1.41 | 6.7 | 6.1 | 10.6 | 75.2 | 56 | 34 | 31 | 4 | 51 | 88 | 0 | 6 | 2 | 0 | 0 | 2 | 3 | 3.47 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 93 | 67 | 0 | 5 | 0 | 3.58 | .282 | 1.10 | 6.7 | 3.2 | 7.9 | 73.0 | 54 | 32 | 29 | 4 | 26 | 64 | 0 | 3 | 1 | 0 | 0 | 6 | 4 | 3.27 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 82 | 54 | 0 | 4 | 3 | 4.34 | .380 | 1.75 | 8.6 | 7.4 | 8.0 | 45.2 | 43 | 27 | 22 | 3 | 37 | 40 | 0 | 5 | 3 | 0 | 0 | 4 | 1 | 4.82 |
| RP | Strop, P.Strop, Pedro # >> | 31 | 2016 | R | 74 | 45 | 0 | 2 | 3 | 5.26 | .362 | 1.67 | 10.0 | 5.4 | 9.7 | 37.2 | 41 | 26 | 22 | 4 | 22 | 40 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 4.11 |
| RP | Ramsdell, W.Ramsdell, Willie >> | 36 | 1952 | R | 43 | 29 | 0 | 5 | 1 | 2.03 | .256 | 1.03 | 5.5 | 3.8 | 7.3 | 31.0 | 19 | 9 | 7 | 2 | 13 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.48 |
| RP | Vaughn, H.Vaughn, Hippo >> | 25 | 1913 | L | 20 | 68 | 0 | 2 | 1 | 2.66 | .308 | 1.26 | 7.2 | 4.2 | 6.5 | 64.1 | 51 | 25 | 19 | 4 | 30 | 46 | 0 | 9 | 1 | 0 | 0 | 5 | 3 | 4.02 |