| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 59 | 21 | 21 | 8 | 8 | 5.21 | .321 | 1.37 | 9.5 | 2.9 | 8.8 | 115.2 | 122 | 68 | 67 | 19 | 37 | 112 | 0 | 0 | 0 | 0 | 11 | 5 | 1 | 4.30 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 48 | 21 | 21 | 7 | 7 | 3.56 | .330 | 1.47 | 7.7 | 5.5 | 9.0 | 124.0 | 106 | 49 | 49 | 7 | 76 | 124 | 0 | 0 | 0 | 0 | 12 | 1 | 4 | 3.60 |
| SP | Snell, B.Snell, Blake # >> | 30 | 2023 | L | 44 | 21 | 21 | 7 | 6 | 5.95 | .348 | 1.56 | 7.8 | 6.3 | 8.7 | 104.1 | 90 | 70 | 69 | 9 | 73 | 101 | 0 | 0 | 0 | 0 | 7 | 4 | 5 | 4.40 |
| SP | Pivetta, N.Pivetta, Nick # >> | 32 | 2025 | R | 53 | 21 | 21 | 7 | 10 | 4.47 | .317 | 1.36 | 9.8 | 2.5 | 9.2 | 110.2 | 120 | 59 | 55 | 22 | 31 | 113 | 0 | 0 | 0 | 0 | 9 | 3 | 1 | 4.47 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 42 | 11 | 10 | 4 | 1 | 4.33 | .316 | 1.38 | 9.2 | 3.3 | 7.8 | 52.0 | 53 | 25 | 25 | 6 | 19 | 45 | 0 | 1 | 0 | 0 | 5 | 0 | 2 | 3.87 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 94 | 60 | 0 | 1 | 1 | 3.72 | .263 | 1.07 | 6.0 | 3.7 | 7.6 | 65.1 | 43 | 27 | 27 | 3 | 27 | 55 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 3.15 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 60 | 33 | 0 | 2 | 2 | 3.82 | .312 | 1.33 | 8.2 | 3.9 | 6.7 | 35.1 | 32 | 19 | 15 | 3 | 15 | 26 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 53 | 70 | 0 | 0 | 2 | 3.78 | .289 | 1.22 | 8.0 | 3.1 | 8.4 | 47.2 | 42 | 20 | 20 | 5 | 16 | 44 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 3.53 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 63 | 38 | 0 | 2 | 3 | 4.05 | .333 | 1.46 | 9.8 | 3.5 | 8.6 | 46.2 | 50 | 21 | 21 | 4 | 18 | 44 | 0 | 6 | 2 | 0 | 0 | 2 | 2 | 3.52 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 79 | 37 | 0 | 0 | 2 | 4.14 | .311 | 1.31 | 8.3 | 3.5 | 8.3 | 41.1 | 38 | 19 | 19 | 5 | 16 | 38 | 0 | 4 | 0 | 0 | 0 | 2 | 2 | 4.05 |