| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 59 | 23 | 23 | 8 | 10 | 5.56 | .324 | 1.40 | 9.7 | 2.9 | 8.7 | 124.2 | 134 | 78 | 77 | 20 | 40 | 120 | 0 | 0 | 0 | 0 | 11 | 5 | 1 | 4.25 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 48 | 23 | 23 | 7 | 7 | 3.36 | .325 | 1.42 | 7.7 | 5.2 | 9.3 | 136.2 | 116 | 52 | 51 | 8 | 78 | 140 | 0 | 0 | 0 | 0 | 14 | 3 | 4 | 3.49 |
| SP | Snell, B.Snell, Blake # >> | 30 | 2023 | L | 44 | 23 | 23 | 7 | 7 | 6.11 | .349 | 1.57 | 7.7 | 6.5 | 8.9 | 113.1 | 97 | 78 | 77 | 12 | 81 | 112 | 0 | 0 | 0 | 0 | 7 | 4 | 8 | 4.65 |
| SP | Pivetta, N.Pivetta, Nick # >> | 32 | 2025 | R | 53 | 23 | 23 | 7 | 10 | 4.79 | .324 | 1.40 | 10.0 | 2.6 | 9.1 | 120.1 | 133 | 68 | 64 | 26 | 35 | 121 | 0 | 0 | 0 | 0 | 10 | 5 | 1 | 4.80 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 42 | 13 | 12 | 4 | 2 | 4.55 | .331 | 1.48 | 10.0 | 3.4 | 8.4 | 61.1 | 68 | 32 | 31 | 8 | 23 | 57 | 0 | 1 | 0 | 0 | 5 | 0 | 2 | 3.97 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 94 | 66 | 0 | 1 | 1 | 3.77 | .271 | 1.12 | 6.2 | 3.9 | 7.7 | 71.2 | 49 | 33 | 30 | 3 | 31 | 61 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 3.14 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 60 | 38 | 0 | 2 | 2 | 4.50 | .341 | 1.53 | 9.5 | 4.3 | 7.0 | 40.0 | 42 | 24 | 20 | 3 | 19 | 31 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.93 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 53 | 77 | 0 | 0 | 3 | 4.10 | .291 | 1.23 | 7.8 | 3.5 | 8.3 | 52.2 | 45 | 24 | 24 | 7 | 20 | 48 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 4.06 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 63 | 45 | 0 | 3 | 5 | 4.02 | .328 | 1.43 | 9.2 | 3.7 | 8.7 | 56.0 | 57 | 25 | 25 | 5 | 23 | 54 | 0 | 6 | 3 | 0 | 0 | 2 | 2 | 3.57 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 79 | 41 | 0 | 0 | 3 | 4.06 | .314 | 1.31 | 8.2 | 3.7 | 8.2 | 44.1 | 40 | 20 | 20 | 5 | 18 | 40 | 0 | 4 | 0 | 0 | 0 | 3 | 2 | 4.09 |