| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 100 | 21 | 21 | 8 | 3 | 3.22 | .300 | 1.27 | 8.0 | 3.5 | 10.3 | 120.1 | 106 | 53 | 43 | 8 | 47 | 137 | 0 | 0 | 0 | 0 | 11 | 2 | 0 | 2.81 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 98 | 21 | 21 | 9 | 9 | 3.34 | .296 | 1.22 | 7.8 | 3.2 | 8.7 | 143.0 | 124 | 60 | 53 | 13 | 51 | 139 | 7 | 0 | 0 | 1 | 14 | 5 | 2 | 3.41 |
| SP | Perez, P.Perez, Pascual >> | 30 | 1987 | R | 80 | 21 | 21 | 0 | 2 | 3.57 | .306 | 1.30 | 8.3 | 3.4 | 5.9 | 53.0 | 49 | 23 | 21 | 8 | 20 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.83 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 74 | 23 | 22 | 4 | 9 | 5.46 | .322 | 1.37 | 8.7 | 3.6 | 10.2 | 117.0 | 113 | 79 | 71 | 9 | 47 | 133 | 1 | 0 | 0 | 1 | 9 | 7 | 4 | 3.11 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 60 | 0 | 13 | 2 | 2.58 | .245 | 0.98 | 6.0 | 2.9 | 9.0 | 69.2 | 46 | 21 | 20 | 3 | 22 | 69 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 2.52 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 92 | 55 | 0 | 7 | 2 | 4.21 | .324 | 1.39 | 8.1 | 4.4 | 6.6 | 94.0 | 85 | 54 | 44 | 14 | 46 | 69 | 0 | 4 | 0 | 0 | 0 | 4 | 3 | 5.06 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 91 | 50 | 0 | 3 | 4 | 2.93 | .266 | 1.07 | 6.0 | 3.7 | 9.2 | 73.2 | 49 | 29 | 24 | 8 | 30 | 75 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 3.64 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 87 | 48 | 0 | 6 | 3 | 4.04 | .305 | 1.30 | 9.1 | 2.6 | 8.7 | 69.0 | 70 | 38 | 31 | 4 | 20 | 67 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 2.72 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 75 | 43 | 0 | 5 | 3 | 4.02 | .368 | 1.74 | 10.0 | 5.7 | 9.8 | 47.0 | 52 | 29 | 21 | 5 | 30 | 51 | 0 | 3 | 7 | 0 | 0 | 0 | 1 | 4.13 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 66 | 42 | 0 | 4 | 1 | 4.59 | .361 | 1.65 | 8.6 | 6.2 | 8.8 | 49.0 | 47 | 27 | 25 | 2 | 34 | 48 | 0 | 3 | 4 | 0 | 0 | 2 | 4 | 3.78 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 65 | 45 | 0 | 2 | 1 | 2.36 | .305 | 1.29 | 9.0 | 2.8 | 12.2 | 45.2 | 45 | 15 | 12 | 6 | 14 | 61 | 0 | 6 | 2 | 0 | 0 | 1 | 1 | 3.02 |
| RP | Harvey, H.Harvey, Hunter >> | 28 | 2023 | R | 55 | 39 | 0 | 5 | 0 | 3.89 | .294 | 1.20 | 8.1 | 2.9 | 10.8 | 41.2 | 37 | 19 | 18 | 3 | 13 | 49 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 2.66 |