| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 5 | 5 | 1 | 2 | 3.34 | .310 | 1.28 | 9.0 | 2.8 | 8.4 | 29.2 | 29 | 11 | 11 | 1 | 9 | 27 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 2.72 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 96 | 5 | 5 | 1 | 2 | 6.93 | .275 | 1.14 | 9.0 | 1.5 | 8.6 | 24.2 | 24 | 19 | 19 | 5 | 4 | 23 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 4.29 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 85 | 4 | 4 | 0 | 0 | 0.77 | .186 | 0.69 | 3.3 | 3.3 | 2.5 | 11.2 | 4 | 1 | 1 | 1 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.73 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 81 | 5 | 5 | 4 | 0 | 3.65 | .260 | 1.03 | 6.3 | 2.9 | 5.6 | 37.0 | 26 | 15 | 15 | 2 | 12 | 23 | 2 | 0 | 0 | 1 | 3 | 1 | 0 | 3.51 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 70 | 4 | 4 | 1 | 2 | 5.63 | .333 | 1.46 | 9.0 | 4.1 | 11.3 | 24.0 | 24 | 15 | 15 | 1 | 11 | 30 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 2.54 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 82 | 13 | 0 | 1 | 0 | 4.02 | .319 | 1.40 | 8.4 | 4.8 | 8.4 | 15.2 | 14 | 7 | 7 | 3 | 8 | 14 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 80 | 13 | 0 | 0 | 2 | 5.28 | .361 | 1.70 | 9.6 | 6.0 | 6.6 | 15.1 | 16 | 9 | 9 | 2 | 10 | 11 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 5.27 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 85 | 14 | 0 | 0 | 1 | 8.78 | .385 | 1.88 | 11.8 | 5.5 | 8.3 | 13.1 | 17 | 13 | 13 | 5 | 8 | 12 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 8.00 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 90 | 10 | 0 | 0 | 1 | 2.84 | .269 | 1.11 | 5.3 | 5.3 | 6.8 | 12.2 | 7 | 5 | 4 | 1 | 7 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 97 | 15 | 0 | 2 | 2 | 7.07 | .344 | 1.57 | 9.0 | 5.1 | 7.1 | 14.0 | 14 | 11 | 11 | 4 | 8 | 11 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 6.86 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 62 | 8 | 0 | 1 | 0 | 3.75 | .321 | 1.42 | 9.8 | 3.0 | 6.8 | 12.0 | 13 | 6 | 5 | 0 | 4 | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.50 |