| SP | deGrom, J.deGrom, Jacob >> | 34 | 2021 | R | 100 | 31 | 31 | 11 | 12 | 4.37 | .325 | 1.41 | 8.9 | 3.8 | 8.6 | 189.1 | 187 | 96 | 92 | 18 | 80 | 181 | 0 | 0 | 0 | 0 | 12 | 6 | 0 | 3.69 |
| SP | Santana, J.Santana, Johan >> | 26 | 2004 | L | 87 | 31 | 31 | 13 | 10 | 5.34 | .328 | 1.44 | 9.9 | 3.1 | 7.8 | 217.1 | 238 | 138 | 129 | 25 | 75 | 189 | 1 | 0 | 0 | 1 | 11 | 5 | 3 | 3.86 |
| SP | Johnson, R.Johnson, Randy >> | 42 | 2004 | L | 45 | 29 | 29 | 9 | 12 | 5.54 | .337 | 1.49 | 10.3 | 3.1 | 8.7 | 185.1 | 212 | 130 | 114 | 18 | 64 | 178 | 0 | 0 | 0 | 0 | 13 | 6 | 5 | 3.48 |
| SP | Krause, H.Krause, Harry >> | 22 | 1909 | L | 73 | 27 | 25 | 12 | 5 | 5.13 | .336 | 1.50 | 10.1 | 3.4 | 4.9 | 161.1 | 181 | 92 | 92 | 19 | 61 | 87 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 4.65 |
| SP | Hendrix, C.Hendrix, Claude >> | 26 | 1914 | R | 49 | 21 | 16 | 6 | 7 | 5.69 | .354 | 1.63 | 10.0 | 4.7 | 3.9 | 112.1 | 124 | 79 | 71 | 16 | 59 | 48 | 1 | 0 | 0 | 0 | 7 | 2 | 2 | 5.63 |
| RP | Saito, T.Saito, Takashi >> | 38 | 2007 | R | 55 | 65 | 0 | 2 | 5 | 3.07 | .343 | 1.55 | 9.6 | 4.5 | 8.7 | 58.2 | 62 | 25 | 20 | 9 | 29 | 56 | 0 | 13 | 3 | 0 | 0 | 1 | 0 | 4.64 |
| RP | Treinen, B.Treinen, Blake >> | 31 | 2018 | R | 39 | 40 | 0 | 3 | 2 | 4.20 | .341 | 1.55 | 10.6 | 3.6 | 8.6 | 40.2 | 47 | 22 | 19 | 3 | 16 | 38 | 0 | 3 | 4 | 0 | 0 | 0 | 1 | 3.28 |
| RP | Betancourt, R.Betancourt, Rafael >> | 33 | 2007 | R | 41 | 34 | 0 | 5 | 1 | 4.18 | .326 | 1.42 | 9.6 | 3.4 | 4.2 | 32.1 | 34 | 18 | 15 | 5 | 12 | 15 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 5.31 |
| RP | Valverde, J.Valverde, Jose >> | 25 | 2003 | R | 81 | 28 | 0 | 0 | 3 | 5.89 | .368 | 1.66 | 10.3 | 5.0 | 12.0 | 36.2 | 41 | 25 | 24 | 2 | 20 | 48 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 2.97 |