| SP | Zambrano, C.Zambrano, Carlos >> | 31 | 2005 | R | 93 | 9 | 9 | 4 | 2 | 4.91 | .326 | 1.45 | 8.4 | 4.8 | 6.5 | 58.2 | 54 | 34 | 32 | 10 | 31 | 42 | 1 | 0 | 0 | 1 | 4 | 0 | 1 | 5.40 |
| SP | Prior, M.Prior, Mark # >> | 32 | 2005 | R | 87 | 9 | 9 | 5 | 3 | 4.30 | .313 | 1.35 | 8.9 | 3.5 | 11.1 | 60.2 | 59 | 32 | 29 | 9 | 23 | 74 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.68 |
| SP | Williams, J.Williams, Jerome >> | 31 | 2005 | R | 77 | 9 | 9 | 2 | 4 | 6.10 | .329 | 1.43 | 9.4 | 3.7 | 7.4 | 51.2 | 53 | 40 | 35 | 7 | 21 | 42 | 1 | 0 | 0 | 0 | 2 | 2 | 0 | 4.49 |
| RP | Aardsma, D.Aardsma, David >> | 31 | 2006 | R | 88 | 22 | 0 | 1 | 1 | 3.94 | .324 | 1.41 | 9.3 | 3.4 | 9.6 | 32.0 | 33 | 16 | 14 | 3 | 12 | 34 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.31 |
| RP | Marshall, S.Marshall, Sean >> | 30 | 2010 | L | 79 | 25 | 0 | 1 | 1 | 3.71 | .322 | 1.39 | 8.3 | 4.5 | 9.0 | 26.2 | 24 | 13 | 11 | 4 | 13 | 26 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.62 |
| RP | Wuertz, M.Wuertz, Michael >> | 34 | 2009 | R | 76 | 21 | 0 | 0 | 0 | 3.38 | .309 | 1.34 | 8.5 | 4.0 | 9.5 | 18.2 | 17 | 12 | 7 | 2 | 8 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Guzman, A.Guzman, Angel >> | 31 | 2009 | R | 59 | 14 | 0 | 1 | 1 | 3.31 | .258 | 1.04 | 6.2 | 3.4 | 8.4 | 16.1 | 11 | 6 | 6 | 3 | 6 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.69 |
| CL | Marmol, C.Marmol, Carlos >> | 30 | 2008 | R | 96 | 18 | 0 | 0 | 3 | 4.02 | .373 | 1.79 | 9.6 | 7.2 | 15.6 | 15.2 | 16 | 7 | 7 | 1 | 12 | 26 | 0 | 8 | 1 | 0 | 0 | 0 | 1 | 2.80 |