| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 89 | 35 | 35 | 13 | 12 | 3.81 | .284 | 1.16 | 8.0 | 2.4 | 8.7 | 241.0 | 215 | 107 | 102 | 29 | 64 | 232 | 2 | 0 | 0 | 0 | 21 | 8 | 4 | 3.54 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 79 | 33 | 33 | 10 | 13 | 5.22 | .321 | 1.38 | 9.3 | 3.1 | 4.7 | 203.1 | 210 | 125 | 118 | 36 | 71 | 105 | 5 | 0 | 0 | 0 | 15 | 8 | 4 | 5.44 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 55 | 32 | 32 | 7 | 17 | 5.97 | .330 | 1.47 | 10.8 | 2.4 | 5.5 | 190.0 | 229 | 130 | 126 | 37 | 51 | 117 | 5 | 0 | 0 | 2 | 11 | 1 | 3 | 5.12 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 26 | 1986 | L | 20 | 32 | 32 | 10 | 13 | 4.05 | .331 | 1.46 | 9.7 | 3.5 | 6.1 | 208.2 | 225 | 102 | 94 | 23 | 80 | 142 | 3 | 0 | 0 | 1 | 19 | 5 | 8 | 4.30 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 61 | 81 | 0 | 7 | 3 | 3.33 | .303 | 1.28 | 7.3 | 4.2 | 9.5 | 92.0 | 75 | 36 | 34 | 5 | 43 | 97 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.07 |
| RP | Hiller, J.Hiller, John >> | 30 | 1973 | L | 37 | 66 | 0 | 6 | 0 | 2.84 | .296 | 1.20 | 7.3 | 3.6 | 5.4 | 63.1 | 51 | 20 | 20 | 7 | 25 | 38 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 4.62 |
| CL | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 96 | 61 | 0 | 8 | 4 | 3.04 | .292 | 1.24 | 7.9 | 3.3 | 8.6 | 71.0 | 62 | 24 | 24 | 7 | 26 | 68 | 0 | 27 | 5 | 0 | 0 | 0 | 4 | 3.46 |
| SP | Ferrell, W.Ferrell, Wes >> | 22 | 1930 | R | 3 | 13 | 0 | 2 | 0 | 6.97 | .340 | 1.50 | 9.9 | 4.1 | 5.4 | 20.2 | 22 | 16 | 16 | 3 | 9 | 12 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 5.25 |
| RP | Hernandez, R.Hernandez, Roberto >> | 32 | 1996 | R | 10 | 43 | 0 | 3 | 0 | 4.31 | .316 | 1.38 | 8.0 | 4.5 | 5.8 | 56.1 | 50 | 27 | 27 | 5 | 28 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 4.38 |