| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 88 | 31 | 31 | 16 | 9 | 3.21 | .288 | 1.20 | 7.5 | 3.3 | 5.6 | 227.1 | 188 | 94 | 81 | 20 | 84 | 142 | 6 | 0 | 0 | 2 | 23 | 4 | 7 | 4.06 |
| SP | Wood, W.Wood, Wilbur # >> | 30 | 1971 | L | 72 | 30 | 30 | 13 | 8 | 3.76 | .267 | 1.08 | 7.8 | 1.9 | 5.5 | 213.0 | 184 | 93 | 89 | 36 | 46 | 129 | 6 | 0 | 0 | 1 | 19 | 3 | 2 | 4.68 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 59 | 23 | 23 | 13 | 6 | 5.00 | .339 | 1.53 | 10.7 | 3.1 | 5.0 | 144.0 | 171 | 94 | 80 | 23 | 49 | 80 | 2 | 0 | 0 | 0 | 12 | 2 | 1 | 5.03 |
| RP | Thigpen, B.Thigpen, Bobby >> | 27 | 1990 | R | 54 | 34 | 0 | 1 | 4 | 3.32 | .278 | 1.13 | 7.1 | 3.1 | 5.4 | 38.0 | 30 | 16 | 14 | 2 | 13 | 23 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 3.58 |
| RP | Hernandez, R.Hernandez, Roberto >> | 32 | 1996 | R | 21 | 21 | 0 | 0 | 1 | 5.24 | .323 | 1.43 | 10.6 | 2.5 | 9.4 | 22.1 | 26 | 13 | 13 | 6 | 6 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.27 |
| SU | Foulke, K.Foulke, Keith # >> | 27 | 1999 | R | 81 | 44 | 0 | 2 | 2 | 5.70 | .344 | 1.50 | 9.2 | 4.5 | 8.4 | 42.2 | 43 | 28 | 27 | 5 | 21 | 39 | 0 | 4 | 8 | 0 | 0 | 3 | 0 | 4.40 |
| CL | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 84 | 56 | 0 | 3 | 11 | 3.36 | .302 | 1.30 | 9.1 | 2.6 | 5.1 | 67.0 | 68 | 28 | 25 | 13 | 19 | 38 | 0 | 26 | 3 | 0 | 0 | 0 | 3 | 5.24 |