| SP | Hernandez, F.Hernandez, Felix # >> | 19 | 2005 | R | 96 | 17 | 17 | 6 | 10 | 3.65 | .293 | 1.20 | 7.6 | 3.2 | 6.7 | 125.2 | 106 | 54 | 51 | 15 | 45 | 93 | 3 | 0 | 0 | 1 | 10 | 5 | 5 | 4.27 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 16 | 16 | 3 | 6 | 6.64 | .314 | 1.34 | 9.0 | 3.2 | 5.8 | 59.2 | 59 | 47 | 44 | 13 | 21 | 38 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.75 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 16 | 16 | 2 | 12 | 7.46 | .369 | 1.71 | 12.1 | 3.3 | 6.4 | 89.1 | 120 | 83 | 74 | 18 | 33 | 63 | 1 | 0 | 0 | 0 | 3 | 4 | 2 | 5.46 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 49 | 16 | 16 | 8 | 5 | 4.87 | .339 | 1.52 | 10.6 | 3.1 | 6.5 | 94.1 | 111 | 53 | 51 | 12 | 32 | 68 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 4.30 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 44 | 0 | 4 | 4 | 5.40 | .315 | 1.31 | 9.0 | 3.0 | 9.9 | 61.2 | 61 | 41 | 37 | 13 | 20 | 67 | 0 | 3 | 2 | 0 | 0 | 4 | 3 | 4.75 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 32 | 0 | 0 | 2 | 3.62 | .321 | 1.39 | 7.5 | 5.1 | 8.3 | 37.1 | 31 | 15 | 15 | 4 | 21 | 34 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 35 | 30 | 0 | 2 | 0 | 3.50 | .292 | 1.17 | 6.3 | 4.4 | 11.7 | 43.2 | 30 | 17 | 17 | 6 | 21 | 56 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.88 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 24 | 30 | 0 | 0 | 0 | 4.08 | .287 | 1.21 | 8.8 | 2.3 | 11.3 | 39.2 | 38 | 19 | 18 | 6 | 10 | 49 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.26 |
| SP | Jurrjens, J.Jurrjens, Jair >> | 23 | 2009 | R | 23 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Patterson, J.Patterson, John >> | 27 | 2005 | R | 34 | 21 | 0 | 2 | 2 | 4.22 | .356 | 1.66 | 11.3 | 3.7 | 5.6 | 32.0 | 40 | 21 | 15 | 6 | 13 | 20 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 5.41 |