| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 29 | 29 | 4 | 9 | 4.47 | .332 | 1.46 | 9.3 | 3.8 | 9.5 | 133.0 | 138 | 68 | 66 | 11 | 56 | 141 | 0 | 0 | 0 | 0 | 1 | 4 | 10 | 3.31 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 67 | 27 | 27 | 7 | 14 | 4.96 | .313 | 1.36 | 9.7 | 2.6 | 5.6 | 176.0 | 189 | 98 | 97 | 28 | 50 | 110 | 1 | 0 | 0 | 1 | 11 | 2 | 2 | 4.70 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 52 | 26 | 26 | 7 | 11 | 5.47 | .342 | 1.56 | 9.7 | 4.3 | 6.4 | 158.0 | 171 | 100 | 96 | 25 | 75 | 112 | 0 | 0 | 0 | 0 | 11 | 0 | 5 | 5.06 |
| RP | Rhodes, A.Rhodes, Arthur # >> | 32 | 2001 | L | 83 | 68 | 0 | 3 | 7 | 5.91 | .310 | 1.34 | 9.5 | 2.6 | 12.0 | 91.1 | 96 | 61 | 60 | 16 | 26 | 121 | 0 | 7 | 8 | 0 | 0 | 1 | 2 | 3.52 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 61 | 0 | 8 | 3 | 4.81 | .318 | 1.36 | 9.4 | 3.0 | 10.3 | 76.2 | 79 | 44 | 41 | 18 | 25 | 87 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 4.89 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 51 | 43 | 0 | 7 | 4 | 3.95 | .285 | 1.14 | 8.1 | 2.2 | 5.8 | 57.0 | 51 | 27 | 25 | 7 | 14 | 37 | 0 | 2 | 3 | 0 | 0 | 3 | 1 | 4.19 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 42 | 46 | 0 | 2 | 3 | 3.51 | .289 | 1.20 | 8.2 | 2.6 | 6.3 | 59.0 | 54 | 27 | 23 | 8 | 17 | 41 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 4.29 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 3 | 0 | 0 | 1 | 18.00 | .438 | 2.33 | 15.0 | 6.0 | 6.0 | 3.0 | 5 | 6 | 6 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.00 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 20 | 0 | 1 | 4 | 13.32 | .443 | 2.34 | 14.3 | 7.1 | 11.6 | 24.1 | 38 | 36 | 36 | 7 | 19 | 31 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 6.71 |