| SP | Harden, R.Harden, Rich † >> | 27 | 2008 | R | 95 | 17 | 17 | 8 | 2 | 2.67 | .300 | 1.25 | 6.3 | 4.9 | 11.0 | 104.1 | 73 | 31 | 31 | 7 | 57 | 127 | 0 | 0 | 0 | 0 | 11 | 4 | 2 | 3.19 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 87 | 16 | 16 | 10 | 4 | 3.91 | .284 | 1.17 | 8.5 | 2.0 | 6.8 | 106.0 | 100 | 48 | 46 | 16 | 24 | 80 | 6 | 0 | 0 | 2 | 8 | 2 | 0 | 4.19 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 16 | 16 | 7 | 2 | 3.55 | .272 | 1.09 | 6.5 | 3.3 | 7.7 | 99.0 | 72 | 41 | 39 | 13 | 36 | 85 | 1 | 0 | 0 | 1 | 9 | 3 | 2 | 4.17 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 16 | 16 | 9 | 1 | 4.50 | .328 | 1.45 | 10.1 | 2.9 | 7.5 | 92.0 | 103 | 48 | 46 | 10 | 30 | 77 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 3.78 |
| SP | Millwood, K.Millwood, Kevin † >> | 28 | 2002 | R | 52 | 16 | 16 | 12 | 0 | 2.99 | .296 | 1.26 | 7.6 | 3.8 | 6.8 | 87.1 | 73 | 30 | 29 | 10 | 37 | 66 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 4.25 |
| RP | Neshek, P.Neshek, Pat † >> | 26 | 2006 | R | 94 | 43 | 0 | 9 | 1 | 2.12 | .264 | 1.01 | 6.8 | 2.4 | 12.0 | 68.0 | 51 | 16 | 16 | 2 | 18 | 91 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 1.68 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 26 | 0 | 3 | 0 | 3.09 | .294 | 1.19 | 5.3 | 5.3 | 9.6 | 32.0 | 19 | 11 | 11 | 1 | 19 | 34 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 3.25 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 32 | 0 | 4 | 2 | 3.07 | .305 | 1.32 | 8.6 | 3.3 | 10.8 | 41.0 | 39 | 17 | 14 | 3 | 15 | 49 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 2.66 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 27 | 0 | 1 | 0 | 2.64 | .264 | 1.04 | 6.3 | 3.3 | 9.0 | 30.2 | 21 | 9 | 9 | 3 | 11 | 30 | 0 | 9 | 1 | 0 | 0 | 1 | 1 | 3.50 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 21 | 0 | 3 | 1 | 3.33 | .336 | 1.44 | 8.6 | 4.5 | 7.9 | 24.1 | 23 | 10 | 9 | 3 | 12 | 21 | 0 | 4 | 0 | 0 | 0 | 2 | 1 | 4.63 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 31 | 0 | 2 | 0 | 3.40 | .274 | 1.08 | 8.8 | 1.2 | 5.8 | 39.2 | 38 | 15 | 15 | 5 | 5 | 25 | 0 | 4 | 0 | 0 | 0 | 2 | 1 | 3.92 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 54 | 6 | 0 | 0 | 0 | 9.82 | .476 | 2.45 | 18.0 | 9.0 | 6.0 | 3.2 | 6 | 4 | 4 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.67 |