| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 29 | 29 | 10 | 9 | 4.22 | .305 | 1.28 | 8.3 | 3.3 | 9.5 | 194.0 | 178 | 92 | 91 | 23 | 71 | 205 | 2 | 0 | 0 | 2 | 19 | 6 | 5 | 3.62 |
| SP | Peavy, J.Peavy, Jake $$ >> | 26 | 2007 | R | 89 | 28 | 28 | 10 | 11 | 4.30 | .317 | 1.35 | 8.8 | 3.3 | 8.6 | 176.0 | 173 | 91 | 84 | 24 | 65 | 168 | 0 | 0 | 0 | 0 | 16 | 7 | 1 | 4.09 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 28 | 27 | 6 | 11 | 6.92 | .371 | 1.73 | 11.9 | 3.7 | 9.5 | 148.1 | 196 | 116 | 114 | 31 | 61 | 156 | 0 | 0 | 0 | 0 | 6 | 6 | 5 | 4.97 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 28 | 26 | 11 | 6 | 6.05 | .363 | 1.66 | 11.8 | 3.2 | 9.1 | 147.1 | 193 | 99 | 99 | 25 | 52 | 148 | 0 | 0 | 0 | 0 | 8 | 7 | 3 | 4.40 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 69 | 0 | 6 | 3 | 3.23 | .284 | 1.14 | 8.0 | 2.3 | 9.0 | 78.0 | 69 | 30 | 28 | 7 | 20 | 78 | 0 | 36 | 6 | 0 | 0 | 4 | 3 | 3.09 |
| SU | Wagner, B.Wagner, Billy $$ >> | 32 | 2003 | L | 90 | 75 | 0 | 5 | 5 | 3.10 | .269 | 1.08 | 6.4 | 3.3 | 10.2 | 87.0 | 62 | 30 | 30 | 10 | 32 | 99 | 0 | 5 | 6 | 0 | 0 | 2 | 6 | 3.39 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 76 | 0 | 6 | 2 | 4.33 | .323 | 1.41 | 7.9 | 4.8 | 10.4 | 81.0 | 71 | 41 | 39 | 10 | 43 | 94 | 0 | 1 | 3 | 0 | 0 | 2 | 8 | 3.95 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 64 | 0 | 3 | 6 | 5.72 | .326 | 1.44 | 9.0 | 4.0 | 9.0 | 72.1 | 72 | 49 | 46 | 18 | 32 | 72 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 5.63 |