| SP | Johnson, R.Johnson, Randy $$ >> | 38 | 2001 | L | 97 | 28 | 28 | 10 | 14 | 3.84 | .307 | 1.29 | 8.1 | 3.6 | 10.7 | 187.2 | 168 | 80 | 80 | 22 | 75 | 222 | 4 | 0 | 0 | 0 | 17 | 6 | 9 | 3.45 |
| SP | Peavy, J.Peavy, Jake $ >> | 26 | 2007 | R | 89 | 27 | 27 | 6 | 14 | 6.89 | .361 | 1.68 | 12.0 | 3.1 | 8.1 | 143.2 | 191 | 111 | 110 | 32 | 50 | 129 | 1 | 0 | 0 | 1 | 7 | 3 | 6 | 5.22 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 28 | 27 | 9 | 8 | 5.71 | .337 | 1.52 | 11.0 | 2.7 | 9.2 | 149.2 | 182 | 95 | 95 | 31 | 45 | 153 | 0 | 0 | 0 | 0 | 12 | 1 | 1 | 4.58 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 27 | 26 | 9 | 6 | 4.64 | .330 | 1.46 | 10.0 | 3.2 | 6.6 | 157.0 | 174 | 82 | 81 | 30 | 55 | 115 | 2 | 0 | 0 | 2 | 13 | 3 | 3 | 5.13 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 30 | 25 | 10 | 12 | 5.97 | .349 | 1.58 | 10.5 | 3.8 | 6.3 | 150.2 | 175 | 106 | 100 | 28 | 63 | 105 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 5.37 |
| CL | Wagner, B.Wagner, Billy $ >> | 32 | 2003 | L | 90 | 61 | 0 | 2 | 8 | 5.45 | .340 | 1.52 | 9.4 | 4.2 | 10.2 | 66.0 | 69 | 42 | 40 | 11 | 31 | 75 | 0 | 28 | 4 | 0 | 0 | 2 | 2 | 4.39 |
| SU | Marmol, C.Marmol, Carlos $ >> | 26 | 2008 | R | 86 | 68 | 0 | 2 | 0 | 3.44 | .315 | 1.35 | 7.3 | 4.9 | 10.1 | 68.0 | 55 | 27 | 26 | 7 | 37 | 76 | 0 | 3 | 0 | 0 | 0 | 2 | 7 | 3.82 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 78 | 0 | 5 | 1 | 1.45 | .276 | 1.12 | 6.4 | 3.8 | 8.2 | 86.2 | 61 | 15 | 14 | 5 | 36 | 78 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 3.27 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 59 | 0 | 4 | 2 | 6.25 | .343 | 1.54 | 10.6 | 3.3 | 8.0 | 72.0 | 85 | 51 | 50 | 19 | 26 | 64 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.82 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 69 | 46 | 0 | 3 | 1 | 5.27 | .332 | 1.46 | 10.3 | 2.9 | 7.9 | 56.1 | 64 | 33 | 33 | 12 | 18 | 49 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.11 |