| SP | Martinez, P.Martinez, Pedro † $$ >> | 29 | 2000 | R | 100 | 27 | 27 | 15 | 6 | 3.42 | .272 | 1.11 | 7.6 | 2.4 | 8.6 | 205.1 | 173 | 82 | 78 | 18 | 54 | 197 | 6 | 0 | 0 | 2 | 19 | 3 | 0 | 3.05 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 86 | 28 | 28 | 10 | 7 | 4.57 | .311 | 1.32 | 9.1 | 2.8 | 8.9 | 181.1 | 183 | 94 | 92 | 23 | 57 | 179 | 0 | 0 | 0 | 0 | 14 | 6 | 4 | 3.72 |
| SP | Carpenter, C.Carpenter, Chris # >> | 34 | 2009 | R | 80 | 27 | 27 | 10 | 10 | 5.74 | .315 | 1.37 | 10.2 | 2.2 | 5.5 | 155.1 | 175 | 102 | 99 | 35 | 38 | 94 | 4 | 0 | 0 | 0 | 11 | 1 | 4 | 5.48 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 27 | 27 | 10 | 11 | 5.29 | .321 | 1.41 | 10.3 | 2.4 | 7.4 | 175.1 | 201 | 103 | 103 | 33 | 47 | 143 | 3 | 0 | 0 | 0 | 12 | 1 | 6 | 4.64 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 26 | 26 | 8 | 10 | 5.89 | .340 | 1.52 | 11.2 | 2.5 | 5.8 | 154.1 | 192 | 108 | 101 | 33 | 42 | 100 | 2 | 0 | 0 | 1 | 9 | 4 | 2 | 5.38 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 33 | 0 | 2 | 2 | 3.68 | .231 | 0.90 | 3.5 | 4.8 | 8.5 | 36.2 | 14 | 16 | 15 | 5 | 19 | 34 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 46 | 0 | 2 | 1 | 2.92 | .276 | 1.13 | 6.6 | 3.6 | 7.6 | 52.1 | 38 | 17 | 17 | 7 | 21 | 44 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 4.33 |
| RP | Valverde, J.Valverde, Jose † >> | 24 | 2003 | R | 80 | 67 | 0 | 9 | 1 | 3.65 | .313 | 1.34 | 7.3 | 4.8 | 11.2 | 81.1 | 66 | 34 | 33 | 6 | 43 | 101 | 0 | 10 | 5 | 0 | 0 | 2 | 2 | 3.14 |
| RP | Betancourt, R.Betancourt, Rafael $ >> | 32 | 2007 | R | 87 | 30 | 0 | 2 | 1 | 2.91 | .320 | 1.38 | 10.6 | 1.9 | 8.5 | 34.0 | 40 | 13 | 11 | 6 | 7 | 32 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.12 |