| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 17 | 17 | 7 | 7 | 3.84 | .303 | 1.27 | 7.5 | 3.9 | 9.6 | 117.1 | 98 | 53 | 50 | 15 | 51 | 125 | 2 | 0 | 0 | 1 | 9 | 4 | 0 | 3.94 |
| SP | Duchscherer, J.Duchscherer, Justin # >> | 31 | 2008 | R | 84 | 16 | 16 | 9 | 4 | 3.86 | .289 | 1.19 | 8.6 | 2.1 | 5.9 | 109.2 | 104 | 48 | 47 | 15 | 26 | 71 | 1 | 0 | 0 | 1 | 9 | 4 | 3 | 4.31 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 16 | 16 | 7 | 5 | 5.40 | .339 | 1.51 | 10.2 | 3.4 | 5.4 | 98.1 | 111 | 59 | 59 | 18 | 37 | 59 | 1 | 0 | 0 | 0 | 7 | 3 | 2 | 5.41 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 17 | 16 | 5 | 6 | 5.55 | .343 | 1.51 | 10.5 | 3.1 | 7.3 | 94.0 | 110 | 66 | 58 | 16 | 32 | 76 | 0 | 0 | 0 | 0 | 7 | 5 | 0 | 4.78 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 42 | 0 | 4 | 2 | 3.13 | .285 | 1.20 | 7.4 | 3.3 | 8.0 | 46.0 | 38 | 16 | 16 | 5 | 17 | 41 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.74 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 31 | 0 | 0 | 2 | 4.18 | .282 | 1.18 | 6.1 | 4.5 | 11.6 | 28.0 | 19 | 13 | 13 | 5 | 14 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.25 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 22 | 0 | 3 | 0 | 6.38 | .353 | 1.58 | 7.0 | 7.5 | 10.5 | 18.1 | 14 | 13 | 13 | 3 | 15 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.50 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 11 | 0 | 0 | 0 | 2.70 | .302 | 1.30 | 9.0 | 2.7 | 5.4 | 10.0 | 10 | 3 | 3 | 1 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 39 | 0 | 3 | 0 | 3.77 | .331 | 1.42 | 8.1 | 4.6 | 9.6 | 31.0 | 28 | 14 | 13 | 4 | 16 | 33 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.29 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 38 | 0 | 0 | 1 | 3.38 | .284 | 1.16 | 5.9 | 4.5 | 5.1 | 32.0 | 21 | 13 | 12 | 2 | 16 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.28 |
| CL | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 28 | 0 | 0 | 2 | 2.93 | .259 | 1.01 | 6.7 | 2.7 | 8.3 | 27.2 | 20 | 9 | 9 | 4 | 8 | 25 | 0 | 17 | 4 | 0 | 0 | 1 | 0 | 4.07 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 20 | 0 | 1 | 1 | 3.20 | .306 | 1.27 | 9.5 | 2.4 | 9.5 | 19.2 | 20 | 7 | 7 | 2 | 5 | 20 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.21 |