| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 100 | 29 | 29 | 11 | 7 | 3.71 | .303 | 1.27 | 8.4 | 3.1 | 9.4 | 172.1 | 160 | 84 | 71 | 26 | 59 | 179 | 0 | 0 | 0 | 0 | 19 | 6 | 1 | 4.02 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 28 | 28 | 2 | 12 | 5.84 | .341 | 1.52 | 10.7 | 3.1 | 8.5 | 155.2 | 184 | 114 | 101 | 29 | 53 | 147 | 1 | 0 | 0 | 0 | 9 | 5 | 2 | 4.66 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 29 | 28 | 11 | 10 | 4.07 | .336 | 1.49 | 9.8 | 3.6 | 6.5 | 159.1 | 174 | 76 | 72 | 18 | 63 | 115 | 0 | 0 | 0 | 0 | 16 | 5 | 3 | 4.31 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 61 | 27 | 26 | 11 | 6 | 4.36 | .319 | 1.39 | 8.7 | 3.8 | 6.9 | 157.0 | 152 | 82 | 76 | 17 | 66 | 120 | 1 | 1 | 0 | 0 | 15 | 3 | 1 | 4.20 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 82 | 0 | 6 | 3 | 3.61 | .269 | 1.10 | 7.7 | 2.3 | 7.6 | 92.1 | 79 | 40 | 37 | 12 | 23 | 78 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.75 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 66 | 0 | 4 | 4 | 3.61 | .306 | 1.26 | 6.8 | 4.6 | 11.5 | 57.1 | 43 | 24 | 23 | 5 | 29 | 73 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 3.32 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 46 | 0 | 1 | 4 | 3.02 | .268 | 1.05 | 7.6 | 2.0 | 9.8 | 44.2 | 37 | 18 | 15 | 7 | 10 | 48 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 3.70 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 72 | 0 | 3 | 2 | 4.98 | .314 | 1.36 | 7.9 | 4.3 | 9.6 | 56.0 | 49 | 31 | 31 | 9 | 27 | 60 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 57 | 32 | 0 | 2 | 3 | 4.85 | .321 | 1.42 | 7.8 | 5.3 | 9.0 | 29.2 | 25 | 16 | 16 | 2 | 17 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.66 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 60 | 0 | 2 | 2 | 5.05 | .366 | 1.73 | 11.0 | 4.6 | 9.4 | 41.0 | 50 | 30 | 23 | 10 | 21 | 43 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 5.61 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 39 | 0 | 1 | 0 | 3.62 | .287 | 1.15 | 7.5 | 2.9 | 8.5 | 37.1 | 31 | 19 | 15 | 6 | 12 | 35 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.35 |
| CL | Nathan, J.Nathan, Joe † $$ >> | 32 | 2006 | R | 98 | 47 | 0 | 8 | 4 | 2.63 | .252 | 0.99 | 6.9 | 2.1 | 10.8 | 51.1 | 39 | 15 | 15 | 5 | 12 | 61 | 0 | 24 | 4 | 0 | 0 | 1 | 1 | 2.65 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 46 | 0 | 1 | 2 | 4.01 | .308 | 1.30 | 7.3 | 4.4 | 9.9 | 49.1 | 40 | 26 | 22 | 7 | 24 | 54 | 0 | 8 | 8 | 0 | 0 | 2 | 1 | 4.24 |