| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 99 | 33 | 33 | 10 | 17 | 3.20 | .261 | 1.03 | 7.0 | 2.3 | 6.4 | 239.0 | 185 | 95 | 85 | 24 | 61 | 170 | 11 | 0 | 0 | 2 | 21 | 7 | 2 | 3.74 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 95 | 33 | 33 | 11 | 11 | 3.36 | .277 | 1.13 | 7.9 | 2.3 | 8.7 | 219.1 | 192 | 85 | 82 | 24 | 56 | 212 | 2 | 0 | 0 | 0 | 22 | 4 | 3 | 3.31 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 91 | 32 | 32 | 19 | 6 | 2.24 | .258 | 1.03 | 6.2 | 3.1 | 8.3 | 221.1 | 153 | 56 | 55 | 13 | 75 | 204 | 1 | 0 | 0 | 0 | 28 | 3 | 2 | 2.98 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 87 | 32 | 32 | 7 | 18 | 4.18 | .294 | 1.24 | 8.0 | 3.1 | 5.4 | 204.2 | 182 | 97 | 95 | 28 | 71 | 123 | 5 | 0 | 0 | 2 | 16 | 3 | 3 | 4.67 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 83 | 32 | 32 | 9 | 21 | 3.94 | .300 | 1.25 | 8.2 | 3.1 | 5.0 | 224.0 | 205 | 106 | 98 | 32 | 76 | 125 | 13 | 0 | 0 | 2 | 17 | 7 | 8 | 4.85 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 99 | 94 | 0 | 3 | 3 | 2.00 | .229 | 0.89 | 4.5 | 3.5 | 9.7 | 90.0 | 45 | 21 | 20 | 9 | 35 | 97 | 0 | 4 | 2 | 0 | 0 | 0 | 2 | 3.31 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 95 | 102 | 0 | 2 | 6 | 3.10 | .259 | 1.05 | 6.9 | 2.5 | 9.6 | 78.1 | 60 | 28 | 27 | 7 | 22 | 83 | 0 | 7 | 4 | 0 | 0 | 0 | 5 | 2.88 |
| RP | Parker, B.Parker, Blake >> | 32 | 2017 | R | 91 | 62 | 0 | 3 | 3 | 2.38 | .249 | 0.99 | 6.9 | 2.1 | 8.3 | 64.1 | 49 | 17 | 17 | 5 | 15 | 59 | 0 | 9 | 0 | 0 | 0 | 0 | 1 | 2.88 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 87 | 39 | 0 | 2 | 4 | 5.52 | .318 | 1.40 | 9.2 | 3.6 | 11.0 | 45.2 | 46 | 29 | 28 | 9 | 18 | 55 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.36 |
| RP | Abad, F.Abad, Fernando >> | 28 | 2014 | L | 84 | 74 | 0 | 2 | 5 | 2.24 | .274 | 1.09 | 6.5 | 3.4 | 5.4 | 72.1 | 52 | 24 | 18 | 3 | 27 | 43 | 0 | 6 | 1 | 0 | 0 | 3 | 0 | 3.60 |