| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 100 | 33 | 33 | 15 | 14 | 3.33 | .261 | 1.04 | 6.9 | 2.5 | 8.9 | 240.2 | 184 | 93 | 89 | 20 | 67 | 236 | 11 | 0 | 0 | 5 | 21 | 4 | 3 | 3.00 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 93 | 33 | 32 | 10 | 13 | 3.40 | .290 | 1.20 | 8.3 | 2.5 | 5.3 | 227.1 | 209 | 90 | 86 | 23 | 64 | 133 | 10 | 0 | 0 | 1 | 20 | 5 | 1 | 4.06 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 85 | 32 | 32 | 13 | 10 | 4.60 | .300 | 1.26 | 8.0 | 3.4 | 4.8 | 203.1 | 180 | 107 | 104 | 29 | 77 | 109 | 8 | 0 | 0 | 1 | 15 | 5 | 2 | 5.00 |
| SP | Hughes, D.Hughes, Dick >> | 29 | 1967 | R | 85 | 32 | 32 | 11 | 11 | 3.61 | .294 | 1.24 | 8.6 | 2.6 | 4.7 | 194.2 | 186 | 86 | 78 | 19 | 56 | 102 | 3 | 0 | 0 | 1 | 19 | 1 | 3 | 4.10 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 97 | 87 | 0 | 10 | 4 | 1.64 | .218 | 0.83 | 5.5 | 2.0 | 7.5 | 115.0 | 70 | 28 | 21 | 9 | 25 | 96 | 0 | 10 | 1 | 0 | 0 | 1 | 3 | 3.03 |
| RP | Soriano, R.Soriano, Rafael >> | 31 | 2010 | R | 90 | 53 | 0 | 4 | 5 | 3.41 | .327 | 1.45 | 8.2 | 4.9 | 6.5 | 66.0 | 60 | 26 | 25 | 10 | 36 | 48 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 5.15 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 89 | 45 | 0 | 4 | 2 | 3.63 | .278 | 1.13 | 7.6 | 2.6 | 8.3 | 52.0 | 44 | 21 | 21 | 4 | 15 | 48 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.08 |
| RP | Thornburg, T.Thornburg, Tyler >> | 27 | 2016 | R | 82 | 35 | 0 | 0 | 3 | 2.85 | .272 | 1.12 | 5.9 | 4.2 | 10.7 | 47.1 | 31 | 15 | 15 | 5 | 22 | 56 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.40 |