| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 20 | 20 | 7 | 9 | 4.56 | .322 | 1.40 | 9.1 | 3.6 | 9.2 | 106.2 | 107 | 56 | 54 | 12 | 42 | 108 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 3.71 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 5 | 8 | 4.21 | .301 | 1.25 | 7.5 | 3.7 | 9.0 | 109.0 | 91 | 60 | 51 | 15 | 45 | 109 | 0 | 0 | 0 | 0 | 10 | 5 | 2 | 4.17 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 80 | 19 | 19 | 6 | 12 | 5.94 | .372 | 1.73 | 11.6 | 4.0 | 3.8 | 94.0 | 121 | 69 | 62 | 17 | 42 | 40 | 0 | 0 | 0 | 0 | 5 | 4 | 1 | 5.97 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 19 | 19 | 5 | 9 | 5.01 | .328 | 1.46 | 9.3 | 3.9 | 4.4 | 118.2 | 122 | 70 | 66 | 11 | 51 | 58 | 3 | 0 | 0 | 0 | 9 | 1 | 3 | 4.55 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 55 | 0 | 2 | 1 | 5.82 | .325 | 1.43 | 9.4 | 3.5 | 7.6 | 65.0 | 68 | 44 | 42 | 13 | 25 | 55 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 5.11 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 74 | 41 | 0 | 2 | 2 | 3.71 | .305 | 1.29 | 6.7 | 4.9 | 9.2 | 51.0 | 38 | 21 | 21 | 3 | 28 | 52 | 0 | 1 | 1 | 0 | 0 | 1 | 9 | 3.43 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 37 | 0 | 3 | 1 | 4.94 | .337 | 1.51 | 9.0 | 4.7 | 5.9 | 58.1 | 58 | 32 | 32 | 7 | 30 | 38 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 4.86 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 28 | 0 | 1 | 2 | 5.16 | .326 | 1.45 | 8.7 | 4.7 | 9.0 | 29.2 | 28 | 17 | 17 | 4 | 15 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.34 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 36 | 0 | 2 | 3 | 3.31 | .307 | 1.33 | 9.0 | 3.1 | 9.0 | 35.1 | 35 | 17 | 13 | 6 | 12 | 35 | 0 | 16 | 5 | 0 | 0 | 0 | 0 | 4.26 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 45 | 0 | 1 | 0 | 3.27 | .279 | 1.15 | 7.5 | 2.8 | 10.5 | 55.0 | 46 | 23 | 20 | 7 | 17 | 64 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 3.31 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 26 | 0 | 1 | 0 | 3.03 | .288 | 1.21 | 7.1 | 4.0 | 9.9 | 29.2 | 23 | 10 | 10 | 4 | 13 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.93 |