| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 20 | 20 | 11 | 4 | 3.36 | .263 | 1.05 | 7.4 | 2.0 | 7.4 | 155.1 | 128 | 58 | 58 | 17 | 35 | 128 | 4 | 0 | 0 | 1 | 12 | 3 | 5 | 3.51 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 61 | 19 | 19 | 11 | 3 | 2.38 | .258 | 1.03 | 6.3 | 3.0 | 4.4 | 139.2 | 97 | 39 | 37 | 13 | 47 | 68 | 2 | 0 | 0 | 0 | 16 | 2 | 1 | 4.29 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 50 | 19 | 19 | 12 | 2 | 2.97 | .281 | 1.15 | 5.8 | 4.6 | 6.5 | 106.0 | 68 | 35 | 35 | 10 | 54 | 77 | 0 | 0 | 0 | 0 | 12 | 2 | 1 | 4.36 |
| SP | Lundgren, C.Lundgren, Carl # >> | 27 | 1907 | R | 44 | 18 | 18 | 6 | 8 | 4.75 | .313 | 1.34 | 7.6 | 4.4 | 3.4 | 106.0 | 90 | 60 | 56 | 9 | 52 | 40 | 2 | 0 | 0 | 0 | 9 | 3 | 2 | 4.91 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 45 | 0 | 3 | 3 | 2.05 | .233 | 0.91 | 4.8 | 3.5 | 8.3 | 26.1 | 14 | 6 | 6 | 0 | 10 | 24 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.31 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 32 | 46 | 0 | 0 | 0 | 4.50 | .340 | 1.55 | 9.0 | 4.9 | 6.5 | 22.0 | 22 | 11 | 11 | 3 | 12 | 16 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.95 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 28 | 0 | 4 | 1 | 1.99 | .181 | 0.66 | 4.5 | 1.6 | 10.6 | 22.2 | 11 | 7 | 5 | 3 | 4 | 26 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.95 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 36 | 29 | 0 | 4 | 1 | 0.86 | .222 | 0.86 | 1.7 | 6.0 | 9.9 | 21.0 | 4 | 2 | 2 | 1 | 14 | 23 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 3.43 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 13 | 0 | 1 | 0 | 0.00 | .179 | 0.65 | 3.0 | 3.0 | 9.0 | 18.1 | 6 | 0 | 0 | 0 | 6 | 18 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 2.00 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 26 | 0 | 7 | 2 | 3.18 | .267 | 1.08 | 6.9 | 2.8 | 4.4 | 65.0 | 50 | 23 | 23 | 6 | 20 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.18 |