| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 91 | 23 | 23 | 6 | 9 | 3.54 | .283 | 1.19 | 7.6 | 3.1 | 8.9 | 140.0 | 118 | 55 | 55 | 19 | 48 | 138 | 1 | 0 | 0 | 0 | 15 | 0 | 0 | 3.82 |
| SP | Zimmermann, J.Zimmermann, Jordan >> | 27 | 2013 | R | 41 | 22 | 22 | 6 | 9 | 4.55 | .301 | 1.26 | 8.7 | 2.7 | 5.8 | 132.2 | 127 | 67 | 67 | 23 | 40 | 85 | 2 | 0 | 0 | 0 | 12 | 4 | 3 | 4.98 |
| SP | Strasburg, S.Strasburg, Stephen >> | 27 | 2016 | R | 46 | 22 | 22 | 3 | 15 | 5.32 | .341 | 1.53 | 10.0 | 3.9 | 9.5 | 116.2 | 129 | 72 | 69 | 13 | 50 | 122 | 1 | 0 | 0 | 0 | 10 | 2 | 4 | 3.70 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 48 | 0 | 7 | 5 | 4.39 | .292 | 1.20 | 8.2 | 2.7 | 9.7 | 53.1 | 48 | 26 | 26 | 11 | 16 | 57 | 0 | 15 | 4 | 0 | 0 | 2 | 1 | 4.57 |
| SU | Albers, M.Albers, Matt >> | 34 | 2017 | R | 78 | 52 | 0 | 0 | 2 | 4.61 | .328 | 1.46 | 9.3 | 4.0 | 7.6 | 52.2 | 54 | 27 | 27 | 6 | 23 | 44 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Harvey, H.Harvey, Hunter >> | 28 | 2023 | R | 49 | 68 | 0 | 4 | 3 | 4.50 | .298 | 1.25 | 8.6 | 2.7 | 8.8 | 80.0 | 76 | 43 | 40 | 17 | 24 | 78 | 0 | 1 | 3 | 0 | 0 | 2 | 3 | 4.79 |
| RP | Storen, D.Storen, Drew >> | 26 | 2014 | R | 45 | 62 | 0 | 3 | 3 | 6.03 | .350 | 1.60 | 12.2 | 2.4 | 5.7 | 71.2 | 96 | 50 | 48 | 9 | 19 | 45 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.23 |
| RP | Murray, D.Murray, Dale >> | 24 | 1974 | R | 43 | 48 | 0 | 2 | 6 | 4.62 | .324 | 1.40 | 7.7 | 4.8 | 4.5 | 78.0 | 67 | 45 | 40 | 7 | 42 | 39 | 0 | 0 | 2 | 0 | 0 | 3 | 1 | 4.90 |
| RP | Weems, J.Weems, Jordan >> | 29 | 2022 | R | 31 | 44 | 0 | 0 | 1 | 6.25 | .374 | 1.77 | 10.8 | 5.3 | 8.4 | 44.2 | 53 | 33 | 31 | 8 | 26 | 41 | 0 | 1 | 2 | 0 | 0 | 1 | 4 | 5.34 |