| SP | McLain, D.McLain, Denny † # >> | 24 | 1968 | R | 87 | 30 | 30 | 20 | 5 | 2.49 | .252 | 0.99 | 7.0 | 2.0 | 6.1 | 253.1 | 196 | 73 | 70 | 28 | 55 | 172 | 17 | 0 | 0 | 3 | 22 | 5 | 1 | 3.79 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 85 | 30 | 30 | 12 | 11 | 4.55 | .290 | 1.18 | 7.9 | 2.8 | 7.7 | 201.2 | 176 | 103 | 102 | 36 | 62 | 171 | 1 | 0 | 0 | 0 | 14 | 9 | 4 | 4.69 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 83 | 29 | 29 | 0 | 3 | 2.11 | .227 | 0.86 | 7.1 | 0.6 | 4.8 | 85.1 | 67 | 21 | 20 | 7 | 6 | 45 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.29 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 79 | 29 | 29 | 7 | 11 | 5.07 | .322 | 1.40 | 10.2 | 2.4 | 9.1 | 165.0 | 187 | 100 | 93 | 27 | 44 | 166 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 3.99 |
| SP | Turnbull, S.Turnbull, Spencer >> | 28 | 2021 | R | 77 | 29 | 29 | 0 | 7 | 3.64 | .301 | 1.28 | 7.8 | 3.8 | 6.8 | 76.2 | 66 | 31 | 31 | 11 | 32 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.68 |
| RP | Greene, S.Greene, Shane † >> | 30 | 2019 | R | 88 | 77 | 0 | 14 | 5 | 2.79 | .260 | 1.03 | 6.3 | 3.1 | 8.9 | 96.2 | 67 | 31 | 30 | 9 | 33 | 95 | 0 | 7 | 3 | 0 | 0 | 2 | 0 | 3.33 |
| RP | Holton, T.Holton, Tyler >> | 28 | 2024 | L | 85 | 71 | 0 | 7 | 4 | 3.83 | .287 | 1.19 | 7.6 | 3.1 | 6.4 | 110.1 | 93 | 49 | 47 | 10 | 38 | 78 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 3.85 |
| RP | Wilson, J.Wilson, Justin † >> | 29 | 2017 | L | 83 | 63 | 0 | 8 | 0 | 3.08 | .309 | 1.32 | 6.5 | 5.4 | 9.6 | 79.0 | 57 | 29 | 27 | 10 | 47 | 84 | 0 | 3 | 6 | 0 | 0 | 2 | 4 | 4.38 |
| RP | Skubal, T.Skubal, Tarik >> | 26 | 2023 | L | 72 | 62 | 0 | 7 | 5 | 4.45 | .324 | 1.42 | 9.8 | 3.0 | 8.6 | 117.1 | 128 | 66 | 58 | 9 | 39 | 112 | 0 | 10 | 5 | 0 | 0 | 2 | 1 | 3.14 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 70 | 44 | 0 | 6 | 1 | 2.08 | .286 | 1.17 | 6.0 | 4.7 | 5.0 | 60.2 | 40 | 15 | 14 | 1 | 31 | 33 | 0 | 5 | 1 | 0 | 0 | 2 | 2 | 3.77 |
| RP | McMahon, D.McMahon, Don † >> | 38 | 1968 | R | 71 | 33 | 0 | 8 | 2 | 2.52 | .258 | 1.02 | 5.3 | 4.1 | 5.1 | 53.2 | 31 | 15 | 15 | 5 | 24 | 30 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 4.51 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 62 | 27 | 0 | 4 | 0 | 3.38 | .316 | 1.39 | 10.4 | 2.4 | 7.6 | 26.2 | 30 | 12 | 10 | 3 | 7 | 22 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.62 |