| SP | Schupp, F.Schupp, Ferdie >> | 25 | 1916 | L | 65 | 12 | 12 | 5 | 4 | 2.17 | .302 | 1.30 | 8.0 | 3.8 | 3.2 | 62.1 | 55 | 21 | 15 | 2 | 26 | 22 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 3.97 |
| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 55 | 12 | 12 | 5 | 6 | 4.33 | .315 | 1.32 | 8.9 | 3.0 | 8.0 | 79.0 | 78 | 42 | 38 | 7 | 26 | 70 | 0 | 0 | 0 | 0 | 5 | 5 | 0 | 3.56 |
| SP | Gonsolin, T.Gonsolin, Tony >> | 28 | 2022 | R | 50 | 12 | 12 | 5 | 5 | 4.70 | .316 | 1.37 | 8.3 | 4.0 | 4.4 | 67.0 | 62 | 35 | 35 | 4 | 30 | 33 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.18 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 61 | 12 | 0 | 0 | 1 | 4.09 | .400 | 1.91 | 9.8 | 7.4 | 12.3 | 11.0 | 12 | 5 | 5 | 0 | 9 | 15 | 0 | 8 | 0 | 0 | 0 | 1 | 0 | 3.00 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 60 | 31 | 0 | 2 | 1 | 3.71 | .277 | 1.09 | 7.7 | 2.1 | 7.9 | 34.0 | 29 | 15 | 14 | 1 | 8 | 30 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 2.50 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 47 | 19 | 0 | 2 | 1 | 4.58 | .344 | 1.42 | 10.4 | 2.8 | 10.4 | 19.2 | 22 | 15 | 10 | 2 | 6 | 22 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.47 |
| RP | Borucki, R.Borucki, Ryan >> | 29 | 2023 | L | 31 | 34 | 0 | 1 | 0 | 3.31 | .300 | 1.22 | 9.3 | 2.0 | 3.7 | 32.2 | 33 | 15 | 12 | 1 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.44 |
| RP | Garcia, Y.Garcia, Yimi >> | 29 | 2020 | R | 20 | 22 | 0 | 0 | 0 | 2.25 | .374 | 1.67 | 9.8 | 5.3 | 9.0 | 24.0 | 26 | 6 | 6 | 0 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.13 |
| SP | Skenes, P.Skenes, Paul >> | 22 | 2024 | R | 25 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 39 | 2 | 0 | 0 | 0 | 4.50 | .400 | 2.00 | 4.5 | 13.5 | 13.5 | 2.0 | 1 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |