| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 9 | 11 | 4.63 | .319 | 1.35 | 9.9 | 2.3 | 9.6 | 167.1 | 183 | 89 | 86 | 25 | 43 | 179 | 0 | 0 | 0 | 0 | 14 | 9 | 2 | 3.74 |
| SP | Glasnow, T.Glasnow, Tyler # >> | 31 | 2025 | R | 88 | 25 | 25 | 8 | 8 | 3.52 | .289 | 1.18 | 6.6 | 4.1 | 10.7 | 130.1 | 95 | 54 | 51 | 11 | 59 | 155 | 0 | 0 | 0 | 0 | 5 | 5 | 2 | 3.19 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 67 | 0 | 6 | 2 | 1.78 | .232 | 0.89 | 5.0 | 3.1 | 10.2 | 70.2 | 39 | 15 | 14 | 4 | 24 | 79 | 0 | 18 | 0 | 0 | 0 | 1 | 4 | 2.56 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 90 | 66 | 0 | 4 | 4 | 4.70 | .315 | 1.34 | 9.1 | 3.1 | 8.6 | 76.2 | 77 | 40 | 40 | 8 | 26 | 73 | 0 | 1 | 6 | 0 | 0 | 3 | 0 | 3.59 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 83 | 70 | 0 | 6 | 3 | 3.78 | .321 | 1.42 | 8.2 | 4.6 | 10.1 | 81.0 | 74 | 34 | 34 | 12 | 41 | 91 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 76 | 62 | 0 | 4 | 3 | 4.11 | .302 | 1.27 | 7.3 | 4.1 | 9.9 | 70.0 | 57 | 32 | 32 | 6 | 32 | 77 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 3.37 |
| RP | Mlodzinski, C.Mlodzinski, Carmen >> | 26 | 2025 | R | 24 | 51 | 0 | 5 | 0 | 5.83 | .353 | 1.63 | 11.3 | 3.5 | 10.0 | 78.2 | 98 | 52 | 51 | 23 | 30 | 87 | 0 | 2 | 4 | 0 | 0 | 1 | 1 | 5.79 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 63 | 21 | 0 | 3 | 3 | 2.14 | .296 | 1.21 | 8.1 | 2.8 | 10.7 | 42.0 | 38 | 10 | 10 | 2 | 13 | 50 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 2.31 |