| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 95 | 29 | 29 | 11 | 8 | 3.14 | .287 | 1.18 | 7.7 | 2.9 | 8.3 | 175.0 | 149 | 65 | 61 | 15 | 57 | 162 | 0 | 0 | 0 | 0 | 19 | 5 | 0 | 3.33 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 87 | 28 | 28 | 1 | 4 | 3.43 | .290 | 1.21 | 7.5 | 3.4 | 4.7 | 76.0 | 63 | 30 | 29 | 8 | 29 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 92 | 28 | 27 | 11 | 9 | 4.10 | .308 | 1.31 | 7.8 | 4.0 | 8.5 | 202.0 | 175 | 96 | 92 | 17 | 90 | 191 | 9 | 0 | 0 | 0 | 13 | 5 | 3 | 3.61 |
| SP | Nabholz, C.Nabholz, Chris >> | 23 | 1990 | L | 76 | 27 | 27 | 0 | 3 | 2.42 | .316 | 1.39 | 7.3 | 5.2 | 6.2 | 67.0 | 54 | 21 | 18 | 4 | 39 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.15 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 80 | 26 | 26 | 12 | 9 | 2.98 | .288 | 1.20 | 7.3 | 3.5 | 5.7 | 187.0 | 152 | 65 | 62 | 13 | 72 | 119 | 2 | 0 | 0 | 1 | 18 | 3 | 6 | 3.83 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 74 | 0 | 7 | 4 | 2.39 | .229 | 0.86 | 5.6 | 2.2 | 9.9 | 105.1 | 65 | 29 | 28 | 8 | 26 | 115 | 0 | 9 | 5 | 0 | 0 | 3 | 3 | 2.63 |
| RP | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 85 | 70 | 0 | 23 | 5 | 2.71 | .263 | 1.05 | 6.6 | 2.9 | 5.0 | 122.2 | 90 | 44 | 37 | 12 | 39 | 68 | 0 | 5 | 2 | 0 | 0 | 2 | 3 | 4.17 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 73 | 58 | 0 | 8 | 1 | 2.51 | .259 | 1.03 | 5.3 | 4.0 | 7.4 | 86.0 | 51 | 25 | 24 | 6 | 38 | 71 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 3.62 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 59 | 57 | 0 | 3 | 0 | 1.81 | .236 | 0.92 | 6.0 | 2.3 | 8.1 | 79.2 | 53 | 20 | 16 | 5 | 20 | 71 | 0 | 11 | 3 | 0 | 0 | 1 | 0 | 2.82 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 57 | 45 | 0 | 6 | 5 | 4.72 | .302 | 1.28 | 9.4 | 2.3 | 10.7 | 47.2 | 49 | 27 | 25 | 13 | 12 | 56 | 0 | 6 | 3 | 0 | 0 | 1 | 1 | 5.04 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 45 | 27 | 0 | 4 | 0 | 3.41 | .291 | 1.23 | 6.7 | 4.6 | 7.3 | 31.2 | 23 | 12 | 12 | 4 | 16 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.61 |
| RP | McGowin, K.McGowin, Kyle >> | 29 | 2021 | R | 37 | 22 | 0 | 1 | 1 | 3.92 | .367 | 1.74 | 9.5 | 6.8 | 9.9 | 20.2 | 21 | 9 | 9 | 2 | 15 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.35 |