| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 53 | 28 | 28 | 8 | 13 | 5.15 | .321 | 1.42 | 8.9 | 3.9 | 7.3 | 183.1 | 181 | 110 | 105 | 25 | 79 | 149 | 1 | 0 | 0 | 1 | 11 | 0 | 5 | 4.44 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 45 | 28 | 28 | 0 | 5 | 4.30 | .293 | 1.24 | 7.5 | 3.7 | 5.7 | 73.1 | 61 | 35 | 35 | 6 | 30 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.04 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 37 | 26 | 26 | 9 | 2 | 4.71 | .339 | 1.50 | 9.1 | 4.5 | 8.0 | 122.1 | 123 | 64 | 64 | 7 | 61 | 109 | 0 | 0 | 0 | 0 | 3 | 4 | 8 | 3.56 |
| SP | Thomson, J.Thomson, John >> | 28 | 2001 | R | 42 | 27 | 27 | 0 | 8 | 6.30 | .390 | 1.88 | 13.1 | 3.9 | 4.5 | 60.0 | 87 | 47 | 42 | 4 | 26 | 30 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.27 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 41 | 27 | 27 | 4 | 12 | 6.41 | .370 | 1.76 | 11.7 | 4.2 | 7.6 | 120.2 | 156 | 87 | 86 | 17 | 56 | 101 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 4.58 |
| RP | Ottavino, A.Ottavino, Adam # >> | 32 | 2018 | R | 63 | 75 | 0 | 14 | 5 | 5.54 | .335 | 1.49 | 7.2 | 6.3 | 8.5 | 92.2 | 74 | 58 | 57 | 15 | 64 | 87 | 0 | 1 | 2 | 0 | 0 | 2 | 9 | 5.38 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 48 | 70 | 0 | 7 | 3 | 3.56 | .275 | 1.11 | 7.0 | 3.0 | 5.4 | 96.0 | 75 | 38 | 38 | 9 | 32 | 58 | 0 | 2 | 6 | 0 | 0 | 2 | 2 | 4.07 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 58 | 67 | 0 | 6 | 4 | 4.68 | .328 | 1.43 | 10.6 | 2.3 | 8.8 | 90.1 | 106 | 47 | 47 | 10 | 23 | 88 | 0 | 0 | 4 | 0 | 0 | 3 | 1 | 3.36 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 55 | 55 | 0 | 3 | 1 | 2.92 | .289 | 1.21 | 6.5 | 4.3 | 7.4 | 77.0 | 56 | 25 | 25 | 8 | 37 | 63 | 0 | 5 | 3 | 0 | 0 | 1 | 5 | 4.19 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 54 | 52 | 0 | 6 | 3 | 4.75 | .330 | 1.45 | 10.6 | 2.5 | 8.5 | 66.1 | 78 | 39 | 35 | 9 | 18 | 62 | 0 | 4 | 4 | 0 | 0 | 2 | 0 | 3.80 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 36 | 46 | 0 | 3 | 0 | 3.90 | .305 | 1.28 | 7.2 | 4.4 | 5.0 | 60.0 | 48 | 27 | 26 | 6 | 29 | 33 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 4.75 |