| SP | Jimenez, U.Jimenez, Ubaldo >> | 25 | 2007 | R | 95 | 29 | 29 | 11 | 8 | 2.79 | .285 | 1.17 | 7.4 | 3.1 | 7.1 | 184.0 | 151 | 59 | 57 | 15 | 64 | 146 | 0 | 0 | 0 | 0 | 22 | 5 | 5 | 3.60 |
| SP | Santana, E.Santana, Ervin # >> | 26 | 2008 | R | 92 | 28 | 28 | 9 | 14 | 4.11 | .307 | 1.32 | 9.1 | 2.7 | 8.5 | 190.2 | 193 | 90 | 87 | 16 | 58 | 179 | 3 | 0 | 0 | 0 | 14 | 2 | 6 | 3.16 |
| SP | Tsao, C.Tsao, Chin-hui >> | 28 | 2003 | R | 90 | 28 | 28 | 13 | 10 | 3.96 | .300 | 1.27 | 8.5 | 2.9 | 6.7 | 168.0 | 159 | 76 | 74 | 12 | 54 | 125 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 3.46 |
| SP | Francis, J.Francis, Jeff # >> | 28 | 2006 | L | 65 | 28 | 28 | 12 | 10 | 4.99 | .326 | 1.43 | 10.2 | 2.7 | 6.4 | 175.0 | 198 | 101 | 97 | 25 | 52 | 125 | 2 | 0 | 0 | 1 | 14 | 4 | 0 | 4.39 |
| RP | Buchholz, T.Buchholz, Taylor >> | 28 | 2008 | R | 96 | 86 | 0 | 4 | 0 | 2.87 | .306 | 1.30 | 7.4 | 4.3 | 8.3 | 81.2 | 67 | 26 | 26 | 3 | 39 | 75 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 3.15 |
| RP | Corpas, M.Corpas, Manuel >> | 27 | 2007 | R | 89 | 73 | 0 | 4 | 0 | 2.10 | .282 | 1.17 | 7.8 | 2.8 | 7.1 | 68.2 | 59 | 16 | 16 | 7 | 21 | 54 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.72 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 30 | 2009 | L | 85 | 82 | 0 | 3 | 1 | 2.50 | .284 | 1.17 | 5.6 | 5.0 | 6.5 | 50.1 | 31 | 15 | 14 | 2 | 28 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 3.82 |
| RP | Betancourt, R.Betancourt, Rafael >> | 34 | 2009 | R | 89 | 45 | 0 | 4 | 2 | 3.63 | .283 | 1.10 | 7.1 | 2.9 | 9.5 | 34.2 | 27 | 14 | 14 | 3 | 11 | 36 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 3.26 |
| RP | Fuentes, B.Fuentes, Brian >> | 34 | 2008 | L | 80 | 42 | 0 | 3 | 1 | 3.21 | .288 | 1.21 | 7.1 | 3.9 | 12.2 | 28.0 | 22 | 10 | 10 | 4 | 12 | 38 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.43 |
| RP | Ramirez, R.Ramirez, Ramon >> | 28 | 2006 | R | 82 | 26 | 0 | 1 | 0 | 3.09 | .273 | 1.13 | 8.7 | 1.4 | 8.2 | 32.0 | 31 | 11 | 11 | 2 | 5 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.47 |
| CL | Street, H.Street, Huston † >> | 26 | 2009 | R | 98 | 60 | 0 | 3 | 5 | 2.31 | .255 | 0.98 | 7.3 | 1.6 | 9.6 | 62.1 | 50 | 18 | 16 | 5 | 11 | 66 | 0 | 42 | 5 | 0 | 0 | 3 | 0 | 2.60 |