| SP | Santana, E.Santana, Ervin † # >> | 25 | 2008 | R | 90 | 29 | 29 | 15 | 9 | 3.72 | .286 | 1.19 | 8.5 | 2.2 | 7.5 | 201.0 | 189 | 86 | 83 | 26 | 50 | 168 | 6 | 0 | 0 | 1 | 18 | 3 | 3 | 3.80 |
| SP | Jimenez, U.Jimenez, Ubaldo # >> | 24 | 2007 | R | 83 | 28 | 28 | 8 | 6 | 4.84 | .315 | 1.32 | 8.4 | 3.5 | 7.8 | 163.2 | 153 | 90 | 88 | 19 | 63 | 142 | 0 | 0 | 0 | 0 | 14 | 10 | 3 | 4.12 |
| SP | Morales, F.Morales, Franklin >> | 22 | 2007 | L | 84 | 28 | 28 | 13 | 4 | 3.57 | .298 | 1.24 | 7.9 | 3.4 | 6.6 | 158.2 | 138 | 64 | 63 | 20 | 59 | 116 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 4.39 |
| SP | Tsao, C.Tsao, Chin-hui >> | 27 | 2003 | R | 75 | 28 | 28 | 7 | 15 | 5.40 | .346 | 1.54 | 9.8 | 4.1 | 7.5 | 151.2 | 164 | 93 | 91 | 27 | 69 | 125 | 1 | 0 | 0 | 1 | 8 | 8 | 0 | 5.20 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 95 | 81 | 0 | 5 | 5 | 3.33 | .284 | 1.17 | 7.7 | 2.9 | 6.8 | 102.2 | 87 | 38 | 38 | 12 | 33 | 77 | 0 | 2 | 2 | 0 | 0 | 2 | 3 | 4.05 |
| RP | Speier, J.Speier, Justin >> | 35 | 2007 | R | 88 | 81 | 0 | 3 | 3 | 2.41 | .299 | 1.26 | 7.7 | 3.6 | 7.7 | 86.0 | 74 | 24 | 23 | 2 | 34 | 74 | 0 | 6 | 4 | 0 | 0 | 2 | 2 | 2.84 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 89 | 92 | 0 | 4 | 2 | 1.99 | .244 | 0.97 | 4.5 | 4.2 | 8.3 | 68.0 | 34 | 17 | 15 | 5 | 32 | 63 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.51 |
| RP | Corpas, M.Corpas, Manuel >> | 26 | 2007 | R | 86 | 69 | 0 | 3 | 6 | 4.07 | .313 | 1.31 | 8.3 | 3.5 | 6.3 | 84.0 | 77 | 39 | 38 | 6 | 33 | 59 | 0 | 7 | 5 | 0 | 0 | 5 | 0 | 3.88 |
| RP | Ramirez, R.Ramirez, Ramon >> | 27 | 2006 | R | 84 | 53 | 0 | 6 | 3 | 1.06 | .254 | 0.98 | 6.9 | 2.0 | 7.5 | 67.2 | 51 | 8 | 8 | 1 | 15 | 56 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 2.33 |
| RP | Dohmann, S.Dohmann, Scott >> | 30 | 2004 | R | 79 | 29 | 0 | 1 | 2 | 3.86 | .364 | 1.61 | 10.8 | 3.9 | 7.2 | 39.2 | 47 | 17 | 17 | 1 | 17 | 31 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 3.36 |