| SP | Jimenez, U.Jimenez, Ubaldo >> | 29 | 2010 | R | 84 | 30 | 30 | 9 | 16 | 3.91 | .300 | 1.26 | 7.3 | 4.1 | 7.8 | 204.2 | 166 | 90 | 89 | 21 | 92 | 177 | 4 | 0 | 0 | 0 | 21 | 5 | 10 | 4.03 |
| SP | Santana, E.Santana, Ervin >> | 30 | 2008 | R | 79 | 30 | 30 | 10 | 13 | 4.78 | .312 | 1.33 | 9.1 | 2.9 | 6.8 | 194.0 | 196 | 107 | 103 | 24 | 62 | 147 | 3 | 0 | 0 | 1 | 15 | 6 | 4 | 4.14 |
| SP | Morales, F.Morales, Franklin >> | 27 | 2007 | L | 89 | 30 | 30 | 12 | 9 | 4.04 | .308 | 1.28 | 7.8 | 3.8 | 7.0 | 180.2 | 156 | 81 | 81 | 15 | 76 | 139 | 1 | 0 | 0 | 1 | 17 | 9 | 0 | 3.96 |
| SP | Chacin, J.Chacin, Jhoulys >> | 25 | 2010 | R | 69 | 30 | 30 | 10 | 5 | 4.89 | .333 | 1.47 | 9.6 | 3.6 | 9.7 | 151.0 | 161 | 82 | 82 | 24 | 61 | 162 | 0 | 0 | 0 | 0 | 7 | 4 | 4 | 4.21 |
| RP | Buchholz, T.Buchholz, Taylor >> | 32 | 2008 | R | 87 | 74 | 0 | 3 | 1 | 2.38 | .277 | 1.12 | 7.2 | 3.0 | 7.5 | 79.1 | 63 | 22 | 21 | 6 | 26 | 66 | 0 | 1 | 3 | 0 | 0 | 2 | 4 | 3.38 |
| RP | Betancourt, R.Betancourt, Rafael >> | 38 | 2011 | R | 83 | 67 | 0 | 6 | 0 | 4.04 | .292 | 1.22 | 7.5 | 3.6 | 9.7 | 55.2 | 46 | 27 | 25 | 7 | 22 | 59 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.76 |
| RP | Corpas, M.Corpas, Manuel >> | 31 | 2007 | R | 84 | 56 | 0 | 4 | 1 | 3.49 | .297 | 1.22 | 8.8 | 2.2 | 7.3 | 49.0 | 48 | 19 | 19 | 6 | 12 | 40 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 3.82 |
| RP | Lopez, J.Lopez, Javier >> | 36 | 2013 | L | 80 | 84 | 0 | 2 | 1 | 4.27 | .295 | 1.20 | 8.1 | 2.8 | 8.5 | 52.2 | 47 | 25 | 25 | 7 | 16 | 49 | 0 | 2 | 3 | 0 | 0 | 3 | 2 | 3.96 |
| RP | Fuentes, B.Fuentes, Brian >> | 38 | 2010 | L | 66 | 42 | 0 | 1 | 2 | 5.40 | .375 | 1.62 | 9.5 | 5.2 | 10.4 | 33.1 | 35 | 21 | 20 | 3 | 19 | 38 | 0 | 0 | 2 | 0 | 0 | 6 | 2 | 4.15 |
| CL | Street, H.Street, Huston >> | 30 | 2012 | R | 100 | 70 | 0 | 4 | 10 | 3.61 | .284 | 1.17 | 6.0 | 4.6 | 8.3 | 67.1 | 45 | 28 | 27 | 8 | 34 | 62 | 0 | 40 | 5 | 0 | 0 | 1 | 2 | 4.27 |
| SP | Tsao, C.Tsao, Chin-hui >> | 32 | 2003 | R | 56 | 27 | 0 | 7 | 2 | 4.84 | .338 | 1.48 | 9.5 | 3.8 | 7.2 | 87.1 | 92 | 47 | 47 | 9 | 37 | 70 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 4.18 |